| Accession | GenProp0482 |
| Name | 6S RNA (eubacterial RNA polymerase regulator) |
| Type | SYSTEM |
| Description | 6S RNA is a structural RNA widely distributed in bacteria. It is considered non-coding, but in many Proteobacteria such as Escherichia coli its ssrS gene is cotranscribed with ygfA, a putative methenyltetrahydrofolate synthetase gene found immediately downstream. 6S RNA functions by binding to the sigma-70 RNA polymerase holoenzyme during stationary phase and suppressing transcription from a subset of sigma-70-dependent promoters. In alpha- and gamma-proteobacteria, the ygfA gene, encoding a putative methylenetetrahydrofolate synthetase, regularly is found immediately downstream of ssrS in a conserved operon. While the meaning of this association is unclear, other than coordination in gene expression, ygfA is included as an optional element for this genome property. |
| JCVI Role | Adaptations to atypical conditions |
| Parent Property | GenProp0462: response to stress
GenProp0819: RNA metabolism
|
| Literature References | [ 1 ]Barrick JE, Sudarsan N, Weinberg Z, Ruzzo WL, Breaker RR 6S RNA is a widespread regulator of eubacterial RNA polymerase that resembles an open promoter. RNA 2005 May;11(5):774-84. PMID 15811922
[ 2 ]Willkomm DK, Minnerup J, Huttenhofer A, Hartmann RK Experimental RNomics in Aquifex aeolicus: identification of small non-coding RNAs and the putative 6S RNA homolog. Nucleic Acids Res 2005 Apr 6;33(6):1949-60. PMID 15814812
[ 3 ]Trotochaud AE, Wassarman KM 6S RNA regulation of pspF transcription leads to altered cell survival at high pH. J Bacteriol. 2006 Jun;188(11):3936-43. PMID 16707685
|
|
