Genome Property Definition Page

AccessionGenProp0492
Namenonhomologous end-joining, bacterial type
TypeSYSTEM
DescriptionThis property describes nonhomologous end-joining (NHEJ), a mechanism for DNA repair of double-stranded breaks that appears significantly less common in bacteria than, and uncorrelated with, recombinational repair. The bacterial Ku protein typically is encoded next to the multidomain, multifunctional DNA ligase, LidD. The domains of LigD, which may be permuted, carry separable 3'-phosphoesterase (PE), DNA ligase, and polymerase activities.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0115: DNA repair
Literature References
[ 1 ]Rocha EP, Cornet E, Michel B  Comparative and evolutionary analysis of the bacterial homologous recombination systems.  PLoS Genet. 2005 Aug;1(2):e15.  PMID 16132081
[ 2 ]Zhu H, Wang LK, Shuman S  Essential constituents of the 3'-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme.  J Biol Chem. 2005 Oct 7;280(40):33707-15.  PMID 16046407
Gene Ontology TermGO:0006303: double-strand break repair via nonhomologous end joining (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
Ku protein, bacterial typeKuYESTIGR02772 (HMM): Ku proteinGO:0006303: double-strand break repair via nonhomologous end joining
3-prime phosphoesterase domainPENOTIGR02777 (HMM): DNA ligase D, 3'-phosphoesterase domainGO:0006303: double-strand break repair via nonhomologous end joining
ligase domainligaseYESTIGR02779 (HMM): DNA ligase D, ligase domainGO:0006303: double-strand break repair via nonhomologous end joining
polymerase domainpolyYESTIGR02778 (HMM): DNA ligase D, polymerase domainGO:0006303: double-strand break repair via nonhomologous end joining

Parent Properties
AccessionName
GenProp0115DNA repair


Sibling Properties
AccessionName
GenProp0114nucleotide excision repair
GenProp0198ruvABC Holliday junction complex
GenProp0215SOS response
GenProp0216recBCD pathway
GenProp0224nucleotide excision repair, alternative pathway
GenProp0225mismatch repair
GenProp0227excision repair
GenProp0228direct repair
GenProp0491recFOR recombination pathway
GenProp0493addAB pathway
GenProp0767very short patch repair