Genome Property Definition Page

AccessionGenProp0493
NameaddAB pathway
TypeSYSTEM
DescriptionThe recBCD pathway, important in double stranded break DNA repair by homologous recombination, is replaced by AddAB in several bacterial lineages. The AddAB gene pairs are quite distant, in terms of sequence similarity, between that of Gram-positive bacteria and that of alphaproteobacteria. Note that an alternative, less common method of repair of double stranded breaks is nonhomologous end-joining (NHEJ), and that pathway may coexist with AddAB in a genome. In some species, AddAB is called RexAB.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0115: DNA repair
Gene Ontology TermGO:0000724: double-strand break repair via homologous recombination (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
AddA proteinAddAYESTIGR02784 (HMM): double-strand break repair helicase AddA
TIGR02785 (HMM): helicase-exonuclease AddAB, AddA subunit
GO:0000724: double-strand break repair via homologous recombination
GO:0000724: double-strand break repair via homologous recombination
AddB proteinAddBYESTIGR02786 (HMM): double-strand break repair protein AddB
TIGR02773 (HMM): helicase-exonuclease AddAB, AddB subunit
TIGR02774 (HMM): ATP-dependent nuclease subunit B
GO:0000724: double-strand break repair via homologous recombination
GO:0000724: double-strand break repair via homologous recombination
GO:0000724: double-strand break repair via homologous recombination

Parent Properties
AccessionName
GenProp0115DNA repair


Sibling Properties
AccessionName
GenProp0114nucleotide excision repair
GenProp0198ruvABC Holliday junction complex
GenProp0215SOS response
GenProp0216recBCD pathway
GenProp0224nucleotide excision repair, alternative pathway
GenProp0225mismatch repair
GenProp0227excision repair
GenProp0228direct repair
GenProp0491recFOR recombination pathway
GenProp0492nonhomologous end-joining, bacterial type
GenProp0767very short patch repair