Genome Property Definition Page

AccessionGenProp0542
NameTol-Pal system
TypeSYSTEM
DescriptionA complex of TolQ, TolR, and TolA in the inner membrane, interacting through TolA with a complex of TolB and Pal (also called OprL) present at the outer membrane, is pivotal to maintaining morphology and outer membrane integrity in many Gram-negative bacteria. The tol operon(s) routinely also contain ybgC (orf1) and ybgF (orf2) genes, although these are not clearly associated with mutant phenotypes. The TolA protein, homologous to TonB from a similar complex, is the most divergent, as it consists largely of very low complexity sequence. TolB contains a variable number of beta-propellar repeats.
Parent PropertyGenProp0012: outer membrane
GenProp0180: small molecule transport
GenProp0012: outer membrane
GenProp0180: small molecule transport
GenProp0012: outer membrane
GenProp0180: small molecule transport
Literature References
[ 1 ]Sturgis JN  Organisation and evolution of the tol-pal gene cluster.  J Mol Microbiol Biotechnol. 2001 Jan;3(1):113-22.  PMID 11200223
[ 2 ]Dubuisson JF, Vianney A, Hugouvieux-Cotte-Pattat N, Lazzaroni JC  Tol-Pal proteins are critical cell envelope components of Erwinia chrysanthemi affecting cell morphology and virulence.  Microbiology. 2005 Oct;151(Pt 10):3337-47.  PMID 16207916
[ 3 ]Llamas MA, Ramos JL, Rodriguez-Herva JJ  Transcriptional organization of the Pseudomonas putida tol-oprL genes.  J Bacteriol. 2003 Jan;185(1):184-95.  PMID 12486055
[ 4 ]Zhuang Z, Song F, Martin BM, Dunaway-Mariano D  The YbgC protein encoded by the ybgC gene of the tol-pal gene cluster of Haemophilus influenzae catalyzes acyl-coenzyme A thioester hydrolysis.  FEBS Lett. 2002 Apr 10;516(1-3):161-3.  PMID 11959124
[ 5 ]Cascales E, Lloubes R, Sturgis JN  The TolQ-TolR proteins energize TolA and share homologies with the flagellar motor proteins MotA-MotB.  Mol Microbiol. 2001 Nov;42(3):795-807.  PMID 11722743
[ 6 ]Cascales E, Lloubes R  Deletion analyses of the peptidoglycan-associated lipoprotein Pal reveals three independent binding sequences including a TolA box.  Mol Microbiol. 2004 Feb;51(3):873-85.  PMID 14731286
[ 7 ]Llamas MA, Rodriguez-Herva JJ, Hancock RE, Bitter W, Tommassen J, Ramos JL  Role of Pseudomonas putida tol-oprL gene products in uptake of solutes through the cytoplasmic membrane.  J Bacteriol. 2003 Aug;185(16):4707-16.  PMID 12896989
[ 1 ]Sturgis JN  Organisation and evolution of the tol-pal gene cluster.  J Mol Microbiol Biotechnol. 2001 Jan;3(1):113-22.  PMID 11200223
[ 2 ]Dubuisson JF, Vianney A, Hugouvieux-Cotte-Pattat N, Lazzaroni JC  Tol-Pal proteins are critical cell envelope components of Erwinia chrysanthemi affecting cell morphology and virulence.  Microbiology. 2005 Oct;151(Pt 10):3337-47.  PMID 16207916
[ 3 ]Llamas MA, Ramos JL, Rodriguez-Herva JJ  Transcriptional organization of the Pseudomonas putida tol-oprL genes.  J Bacteriol. 2003 Jan;185(1):184-95.  PMID 12486055
[ 4 ]Zhuang Z, Song F, Martin BM, Dunaway-Mariano D  The YbgC protein encoded by the ybgC gene of the tol-pal gene cluster of Haemophilus influenzae catalyzes acyl-coenzyme A thioester hydrolysis.  FEBS Lett. 2002 Apr 10;516(1-3):161-3.  PMID 11959124
[ 5 ]Cascales E, Lloubes R, Sturgis JN  The TolQ-TolR proteins energize TolA and share homologies with the flagellar motor proteins MotA-MotB.  Mol Microbiol. 2001 Nov;42(3):795-807.  PMID 11722743
[ 6 ]Cascales E, Lloubes R  Deletion analyses of the peptidoglycan-associated lipoprotein Pal reveals three independent binding sequences including a TolA box.  Mol Microbiol. 2004 Feb;51(3):873-85.  PMID 14731286
[ 7 ]Llamas MA, Rodriguez-Herva JJ, Hancock RE, Bitter W, Tommassen J, Ramos JL  Role of Pseudomonas putida tol-oprL gene products in uptake of solutes through the cytoplasmic membrane.  J Bacteriol. 2003 Aug;185(16):4707-16.  PMID 12896989
[ 1 ]Sturgis JN  Organisation and evolution of the tol-pal gene cluster.  J Mol Microbiol Biotechnol. 2001 Jan;3(1):113-22.  PMID 11200223
[ 2 ]Dubuisson JF, Vianney A, Hugouvieux-Cotte-Pattat N, Lazzaroni JC  Tol-Pal proteins are critical cell envelope components of Erwinia chrysanthemi affecting cell morphology and virulence.  Microbiology. 2005 Oct;151(Pt 10):3337-47.  PMID 16207916
[ 3 ]Llamas MA, Ramos JL, Rodriguez-Herva JJ  Transcriptional organization of the Pseudomonas putida tol-oprL genes.  J Bacteriol. 2003 Jan;185(1):184-95.  PMID 12486055
[ 4 ]Zhuang Z, Song F, Martin BM, Dunaway-Mariano D  The YbgC protein encoded by the ybgC gene of the tol-pal gene cluster of Haemophilus influenzae catalyzes acyl-coenzyme A thioester hydrolysis.  FEBS Lett. 2002 Apr 10;516(1-3):161-3.  PMID 11959124
[ 5 ]Cascales E, Lloubes R, Sturgis JN  The TolQ-TolR proteins energize TolA and share homologies with the flagellar motor proteins MotA-MotB.  Mol Microbiol. 2001 Nov;42(3):795-807.  PMID 11722743
[ 6 ]Cascales E, Lloubes R  Deletion analyses of the peptidoglycan-associated lipoprotein Pal reveals three independent binding sequences including a TolA box.  Mol Microbiol. 2004 Feb;51(3):873-85.  PMID 14731286
[ 7 ]Llamas MA, Rodriguez-Herva JJ, Hancock RE, Bitter W, Tommassen J, Ramos JL  Role of Pseudomonas putida tol-oprL gene products in uptake of solutes through the cytoplasmic membrane.  J Bacteriol. 2003 Aug;185(16):4707-16.  PMID 12896989

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
tol-pal system protein Pal (OprL)PalYESTIGR02802 (HMM): peptidoglycan-associated lipoprotein
TIGR02802 (HMM): peptidoglycan-associated lipoprotein
tol-pal system protein Pal (OprL)PalYESTIGR02802 (HMM): peptidoglycan-associated lipoprotein
TIGR02802 (HMM): peptidoglycan-associated lipoprotein
tol-pal system protein Pal (OprL)PalYESTIGR02802 (HMM): peptidoglycan-associated lipoprotein
TIGR02802 (HMM): peptidoglycan-associated lipoprotein
TolATolAYESTIGR02794 (HMM): protein TolA
TIGR02794 (HMM): protein TolA
TolATolAYESTIGR02794 (HMM): protein TolA
TIGR02794 (HMM): protein TolA
TolATolAYESTIGR02794 (HMM): protein TolA
TIGR02794 (HMM): protein TolA
TolBTolBYESTIGR02800 (HMM): Tol-Pal system beta propeller repeat protein TolB
TIGR02800 (HMM): Tol-Pal system beta propeller repeat protein TolB
TolBTolBYESTIGR02800 (HMM): Tol-Pal system beta propeller repeat protein TolB
TIGR02800 (HMM): Tol-Pal system beta propeller repeat protein TolB
TolBTolBYESTIGR02800 (HMM): Tol-Pal system beta propeller repeat protein TolB
TIGR02800 (HMM): Tol-Pal system beta propeller repeat protein TolB
TolQTolQYESTIGR02796 (HMM): protein TolQ
TIGR02796 (HMM): protein TolQ
TolQTolQYESTIGR02796 (HMM): protein TolQ
TIGR02796 (HMM): protein TolQ
TolQTolQYESTIGR02796 (HMM): protein TolQ
TIGR02796 (HMM): protein TolQ
TolRTolRYESTIGR02801 (HMM): protein TolR
TIGR02801 (HMM): protein TolR
TolRTolRYESTIGR02801 (HMM): protein TolR
TIGR02801 (HMM): protein TolR
TolRTolRYESTIGR02801 (HMM): protein TolR
TIGR02801 (HMM): protein TolR
tol-pal region thioesterase YbgCYbgCNOTIGR02799 (HMM): tol-pal system-associated acyl-CoA thioesterase
TIGR02799 (HMM): tol-pal system-associated acyl-CoA thioesterase
tol-pal region thioesterase YbgCYbgCNOTIGR02799 (HMM): tol-pal system-associated acyl-CoA thioesterase
TIGR02799 (HMM): tol-pal system-associated acyl-CoA thioesterase
tol-pal region thioesterase YbgCYbgCNOTIGR02799 (HMM): tol-pal system-associated acyl-CoA thioesterase
TIGR02799 (HMM): tol-pal system-associated acyl-CoA thioesterase
tol-pal region protein YbgFYbgFNOTIGR02795 (HMM): tol-pal system protein YbgF
TIGR02795 (HMM): tol-pal system protein YbgF
tol-pal region protein YbgFYbgFNOTIGR02795 (HMM): tol-pal system protein YbgF
TIGR02795 (HMM): tol-pal system protein YbgF
tol-pal region protein YbgFYbgFNOTIGR02795 (HMM): tol-pal system protein YbgF
TIGR02795 (HMM): tol-pal system protein YbgF

Parent Properties
AccessionName
GenProp0012outer membrane
GenProp0180small molecule transport
GenProp0012outer membrane
GenProp0180small molecule transport
GenProp0012outer membrane
GenProp0180small molecule transport


Sibling Properties
AccessionName
GenProp0053type II secretion
GenProp0119PTS transport system
GenProp0129Na+-translocating NADH-quinone reductase
GenProp0135NADH dehydrogenase I
GenProp0172Potassium-transporting ATPase KdpFABC
GenProp0176TRAP-T (tripartite ATP-independent periplasmic transporters) family transporters
GenProp0190phosphate ABC transporter (pstSCAB-phoU)
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0192molybdate ABC transporter
GenProp0236phosphonates ABC transport
GenProp0252thiamine/TPP ABC transporter ThiBPQ
GenProp0279cobalt import systems
GenProp0494nickel import ABC transporter
GenProp0543TonB-dependent transport
GenProp0651ectoine ABC transporter EhuABCD
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp07122-aminoethylphosphonate (AEP) ABC transporter, type I, PhnSTUV
GenProp07212-aminoethylphosphonate (AEP) ABC transporter, type II
GenProp0743urea ABC transporter UrtABCDE
GenProp0748choline ABC transporter, ChoXWV family
GenProp0749choline sulfate utilization
GenProp0828heme uptake system, NEAT-domain mediated
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0873ion-motive antiporter cycles