Genome Property Definition Page

NameTonB-dependent transport
DescriptionThe components of a TonB-dependent transport system include ExbB, ExbD, and TonB, respectively homologous to TolQ, TolR, and TolA of related tol-pal system. But while the tol-pal system includes seven genes altogether, including the peptidoglycan associated lipoprotein Pal, and seems required for maintaining integrity of the outer membrane, TonB systems tend to be required for siderophore or B12 uptake when mutant phenotypes are observed. At least two different exbB/exbD gene pair families exist, and two different pairs of HMMs currently model two different classes. The capacity for TonB-dependent transport is also marked by the presence of TonB-dependent transporters, which share a region of homology and may number more than 50 in a single genome.
JCVI RoleUnknown substrate
Parent PropertyGenProp0180: small molecule transport

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
TonB C-terminal domainTonBYESTIGR01352 (HMM-CLUST): TonB family C-terminal domain
barrel domain, tonB-dependent receptorbarrelNOPF00593 (HMM): TonB-dependent receptor
tonB-system energizer ExbBexbBYESTIGR02797 (HMM): tonB-system energizer ExbB
TIGR02805 (HMM): tonB-system energizer ExbB
tonB-system energizer ExbDexbDYESTIGR02803 (HMM): TonB system transport protein ExbD
TIGR02804 (HMM): TonB system transport protein ExbD
plug domain, tonB-dependent receptorplugNOPF07715 (HMM): TonB-dependent receptor plug domain

Parent Properties
GenProp0180small molecule transport

Sibling Properties
GenProp0119PTS transport system
GenProp0129Na+-translocating NADH-quinone reductase
GenProp0135NADH dehydrogenase I
GenProp0172Potassium-transporting ATPase KdpFABC
GenProp0176TRAP-T (tripartite ATP-independent periplasmic transporters) family transporters
GenProp0190phosphate ABC transporter (pstSCAB-phoU)
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0192molybdate ABC transporter
GenProp0236phosphonates ABC transport
GenProp0252thiamine/TPP ABC transporter ThiBPQ
GenProp0279cobalt import systems
GenProp0494nickel import ABC transporter
GenProp0542Tol-Pal system
GenProp0651ectoine ABC transporter EhuABCD
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp07122-aminoethylphosphonate (AEP) ABC transporter, type I, PhnSTUV
GenProp07212-aminoethylphosphonate (AEP) ABC transporter, type II
GenProp0743urea ABC transporter UrtABCDE
GenProp0748choline ABC transporter, ChoXWV family
GenProp0749choline sulfate utilization
GenProp0828heme uptake system, NEAT-domain mediated
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0873ion-motive antiporter cycles