Genome Property Definition Page

AccessionGenProp0611
Nameaerobic respiration
TypeMETAPATH
DescriptionAerobic respiration is the complex series of pathways in which a common organic intermediate (generally pyruvate) is broken down into carbon dioxide (CO2) and water (H20) with the concomitant production of ATP in the presence of oxygen. Pyruvate is generated from glucose via glycolysis. The first step of this process is conversion of pyruvate to acetyl-CoA which then enters the Krebs (or, TCA) cycle. Acetyl-CoA may also be generated independently of pyruvate via the breakdown of other organic compounds. The TCA cycle generates reducing equivalents in the form of NADH. NADH, in turn delivers the electrons to the top of the electron transport chain (oxidative phosphorylation). This chain results in the pumping of protons (and/or sodium ions) to form a gradient. Ions flowing back with this gradient power the ATP-generation machines of the cell. Oxygen acts as the terminal electron acceptor for the electron-transport chain.
Parent PropertyGenProp0070: energy metabolism

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
Generation of a ATP from ADP utilizing a proton (or sodium ion) gradientATPsynthYESGenProp0128 (GENPROP): F1/F0 ATPase
GenProp0629 (GENPROP): A1/A0 ATPase
Generation of a proton (or sodium ion) gradient by the coupling of NADH oxidation (to NAD+) with oxygen reduction (to water)ETCYESGenProp0612 (GENPROP): aerobic electron transfer (transport) chain, ETC
Generation of NADH from NAD+ by oxidation of electron donor moleculesTCAcycYESGenProp0033 (GENPROP): TCA cycle

Parent Properties
AccessionName
GenProp0070energy metabolism

Child Properties
AccessionName
GenProp0033TCA cycle
GenProp0128F1/F0 ATPase
GenProp0612aerobic electron transfer (transport) chain, ETC

Sibling Properties
AccessionName
GenProp0011methanogenesis
GenProp0023glyoxylate shunt
GenProp0027photosynthesis
GenProp0033TCA cycle
GenProp0120pentose phosphate cycle
GenProp0131electron transport
GenProp0243ATP synthases
GenProp0298fermentation
GenProp0459D-xylose utilization (conversion to D-xylulose-5-phosphate)
GenProp0468Entner-Doudoroff pathway
GenProp0473arsenite oxidase
GenProp0636respiratory nitrate reductase
GenProp0637anaerobic dimethyl sulfoxide reductase
GenProp0638trimethylamine N-oxide reductase system
GenProp0682formate-dependent nitrite reductase, seven-gene type
GenProp0683cytochrome c nitrite reductase NrfHA
GenProp0691glycolysis
GenProp0695cytochrome b558/566
GenProp0723hydrogenase, nickel and F420-dependent
GenProp0737anaerobic glycerol-3-phosphate dehydrogenase complex
GenProp0755pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating
GenProp0756fumarate reductase complex
GenProp0764DMSO reductase family type II enzyme
GenProp08412-oxoacid:ferredoxin oxidoreductase
GenProp0856bacterio-opsin system
GenProp0914hydrogenase, [FeFe]-dependent
GenProp0915hydrogenase, mono-iron type
GenProp1089B12-dependent trimeric diol/glycerol dehydratase