Genome Property Definition Page

Namecytochrome c oxidase, mitochondrial, caa3-type
DescriptionThe cytochrome c oxidase complex is responsible for coupling the oxidation of the reduced cytochrome c protein to the reduction of molecular oxygen to form water with the concomitant pumping of protons out of the cell. This complex is the type found in mitochondria and prokaryotes which utilize mitochondrial-type aerobic respiration. The complex in Bacilli [2] is somewhat different but included here and carrys the gene symbols CtaD/CtaC.
JCVI RoleElectron transport
Parent PropertyGenProp0615: cytochrome c based oxygen reduction and quinone re-oxidation
Literature References
[ 1 ]Ostermeier C, Harrenga A, Ermler U, Michel H  Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment.  Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10547-53.  PMID 9380672
[ 2 ]Saraste M, Metso T, Nakari T, Jalli T, Lauraeus M, Van der Oost J  The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved protein theme.  Eur J Biochem. 1991 Jan 30;195(2):517-25.  PMID 1847686

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
oxidase subunit I CoxA/CtaD/Cox1CoxAYESTIGR02891 (HMM): cytochrome c oxidase, subunit I
oxidase subunit II, CoxBCoxBYESTIGR02866 (HMM): cytochrome c oxidase, subunit II
oxidase subunit III, CoxCCoxCYESPF00510 (SUBFAMILY): cytochrome c oxidase subunit III
TIGR02842 (SUBFAM-EX): cytochrome o ubiquinol oxidase, subunit III
TIGR02897 (SUBFAM-EX): cytochrome aa3 quinol oxidase, subunit III
oxidase subunit IV, CoxDCoxDNOTIGR02229 (HMM): caa(3)-type oxidase, subunit IV
PF03626 (HMM): prokaryotic cytochrome c oxidase subunit IV
protoheme IX farnesyltransferase, CtaB/Cox10CoxE?NOTIGR01473 (HMM): protoheme IX farnesyltransferase
assembly protein CoxG/CtaG/Cox11CoxGNOPF04442 (HMM): cytochrome c oxidase assembly protein CtaG/Cox11
assembly protein CoxW/CtaA/Cox15CoxWNOPF02628 (HMM): cytochrome oxidase assembly protein

Parent Properties
GenProp0615cytochrome c based oxygen reduction and quinone re-oxidation

Sibling Properties
GenProp0483cytochrome c oxidase, cbb3-type
GenProp0613cytochrome c reductase