Genome Property Definition Page

Nameprotein sorting system, sortase type, LPXTG/SrtA class
DescriptionThis property describes the common subtype of the sortase system for targeting cell wall proteins in the Firmicutes by recognition of the LPXTG C-terminal motif. The presence of one or more sortases and their target sequences should be universal in Gram-positive organisms with cell walls. Sortase is a transpeptidase; sortases belonging to this Genome Property resemble SrtA, and the sorting signal generally resembles LPXTG. Several SrtA paralogs can be found in some genomes, as well as the substantially different SrtB and other families of sortase and their cognate sequences.
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0069: cell surface component
GenProp0179: protein transport

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
LPXTG-like C-terminal regionLPXTGYESTIGR01167 (HMM): LPXTG cell wall anchor domain
sortase (transpeptidase)sortaseYESTIGR01076 (HMM): sortase

Parent Properties
GenProp0069cell surface component
GenProp0179protein transport

Sibling Properties
GenProp0012outer membrane
GenProp0056type IV pilus
GenProp0158peptidoglycan(murein) biosynthesis
GenProp0297lipopolysaccharide biosynthesis
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0725outer membrane protein assembly complex
GenProp0811S-layer homology domain-mediated cell wall binding
GenProp0857anchored repeat-class ABC transporter, P. acnes type
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N