Genome Property Definition Page

Namegene pair involved in iron and oxygen metabolism
DescriptionThe knockout of SO1377 in Shewanella oneidensis results in oxidative damage related to changes in iron metabolism [1]. The adjacent gene, SO1366 is phylogenomically linked and part of an apparent operon.
JCVI RoleRole category not yet assigned
Parent PropertyGenProp0475: Unknown biological process
GenProp0820: iron metabolism
Literature References
[ 1 ]Gao W, Liu Y, Giometti CS, Tollaksen SL, Khare T, Wu L, Klingeman DM, Fields MW, Zhou J  Knock-out of SO1377 gene, which encodes the member of a conserved hypothetical bacterial protein family COG2268, results in alteration of iron metabolism, increased spontaneous mutation and hydrogen peroxide sensitivity in Shewanella oneidensis MR-1.  BMC Genomics. 2006 Apr 6;7(1):76.  PMID 16600046

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
SO1376 gene familySO1376YES
SO1377 gene family: part of COG2268SO1377YES

Parent Properties
GenProp0475Unknown biological process
GenProp0820iron metabolism

Sibling Properties
GenProp0470sporadically distributed four-gene operon
GenProp0471uncharacterized gene pair TIGR02683/TIGR02684
GenProp0472uncharacterized gene pair TIGR02687/TIGR02688
GenProp0665peptide chain release operon, RctB-like/PrfH
GenProp0751Acidobacterial ADOP/PadR gene pairs
GenProp0790sporadic pair TIGR03545/TIGR03546
GenProp0798Enterococcus/Aeromonas extended locus
GenProp0830integral membrane mystery pair
GenProp0854ParB-rel/ThiF-rel cassette PRTRC
GenProp0868uncharacterized protein pair with twin-arg and repeat
GenProp0894Actinobacterial uncharacterized trio
GenProp0916radical SAM/uncharacterized protein TIGR03936 system
GenProp0940metallo-mystery pair
GenProp0959radical SAM/uncharacterized protein TIGR04002 system
GenProp0965YedE/YedF selenium handling system
GenProp1063Memo/AMMECR1/rSAM family trio system
GenProp1066uncharacterized cassette GAK (Grasp, Amphipathic, Kinase)
GenProp1086Firmicutes/Treponema mobile radical SAM system
GenProp0140iron-sulfur cluster assembly systems
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0222protoheme from protoporphyrin IX
GenProp0770siderophore biosynthesis
GenProp0774ferric citrate transport system
GenProp0828heme uptake system, NEAT-domain mediated
GenProp0961heme metabolism pair HutWX