Genome Property Definition Page

Name2-oxoglutarate dehydrogenase system
DescriptionThis enzyme system utilizes three components E1 (thiamine pyrophosphate-binding subunit, SucA), E2 (dihydrolipoamide succinyltransferase, SucB) and E3 (dihydrolipoamide dehydrogenase, LpdA) for the interconversion of 2-oxoglutarate (alpha-ketoglutarate) and succinyl-CoA. In addition to lipoate and thiamine pyrophosphate, FAD is also involved. In the course of the reaction CO2 is released and and one molecule of NAD+ is converted to NADH. This reaction is an essential component of the TCA (Krebs) cycle.
JCVI RoleTCA cycle
Parent PropertyGenProp0033: TCA cycle

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
thiamine pyrophosphate-binding subunit, SucA (E1)E1YESTIGR00239 (HMM): oxoglutarate dehydrogenase (succinyl-transferring), E1 component
dihydrolipoamide succinyltransferase, SucB (E2)E2YESTIGR01347 (HMM): dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex
TIGR02927 (HMM): 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase
dihydrolipoamide dehydrogenase, LpdA (E3)E3YESTIGR01350 (HMM): dihydrolipoyl dehydrogenase

Parent Properties
GenProp0033TCA cycle