Genome Property Definition Page

Accession

GenProp0640

Name

xanthine dehydrogenase

Type

SYSTEM

Description

Xanthine dehydrogenase is a molydbopterin-containing enzyme. It converts xanthine, from the purine pool, to urate, which is subsequently degraded. In bacteria, the enzyme usually is encoded as a small subunit, XdhA, that contains FAD and 2Fe2S cofactors and a large subunit, XdhB, that contains the molybdopterin cofactor. The accessory protein XdhC is usually but not always encoded next to the XdhAB gene pair.

JCVI Role

Other

Parent Property

GenProp0817: nucleotide catabolism/utilization pathways

Literature References

[ 1 ]Neumann M, Schulte M, Junemann N, Stocklein W, Leimkuhler S Rhodobacter capsulatus XdhC Is Involved in Molybdenum Cofactor Binding and Insertion into Xanthine Dehydrogenase. J Biol Chem. 2006 Jun 9;281(23):15701-8. Epub 2006 Apr 5. PMID 16597619

Components

Step Name	Step Num	Required	Evidence (Method)
xanthine dehydrogenase, 2Fe2S/FAD subunit	xdhA	YES	TIGR02963 (HMM): xanthine dehydrogenase, small subunit
xanthine dehydrogenase, molybdopterin subunit	xdhB	YES	TIGR02965 (HMM): xanthine dehydrogenase, molybdopterin binding subunit
xanthine dehydrogenase accessory protein XdhC	xdhC	YES	TIGR02964 (HMM): xanthine dehydrogenase accessory protein XdhC

Parent Properties

Accession	Name
GenProp0817	nucleotide catabolism/utilization pathways

Sibling Properties

Accession	Name
GenProp0696	xanthine utilization as a source of guanine-monophosphate (GMP)
GenProp0700	purine catabolism via urate, xanthine and allantoin
GenProp0705	xanthine dehydrogenase, bacillus type (pucABCDE)
GenProp0813	pyrimidine utilization operon, RutABCDEFGR