Genome Property Definition Page

AccessionGenProp0648
Namephage shock protein regulon
TypeSYSTEM
DescriptionThis property describes a regulon present in E. coli and a number of other species induced by various stresses including osmotic shock, ethanol, heat, and expression of various secretins, as occurs with infection by certain filamentous phage. A common thread to these stressors may be compromise of the inner membrane and decrease of the protonmotive force. Most proteins of the regulon occur in a single operon, but at least one member, pspG, is located elsewhere in most genomes. The signature genes of the the phage shock regulon are the sigma-54-dependent positive regulator PspF, PspA which binds to and inhibits PspF, and PspB and PspC which act together as both regulatory and effector proteins of the phage shock regulon. PspG occurs in most but not all phage shock-positive genomes, while PspD and PspE are found only in a minority of phage shock operons.
JCVI RoleAdaptations to atypical conditions
Parent PropertyGenProp0074: virulence
GenProp0462: response to stress
GenProp0074: virulence
GenProp0462: response to stress
GenProp0074: virulence
GenProp0462: response to stress
Literature References
[ 1 ]Brissette JL, Weiner L, Ripmaster TL, Model P  Characterization and sequence of the Escherichia coli stress-induced psp operon.  J Mol Biol. 1991 Jul 5;220(1):35-48.  PMID 1712397
[ 2 ]Jovanovic G, Weiner L, Model P  Identification, nucleotide sequence, and characterization of PspF, the transcriptional activator of the Escherichia coli stress-induced psp operon.  J Bacteriol. 1996 Apr;178(7):1936-45.  PMID 8606168
[ 3 ]Lloyd LJ, Jones SE, Jovanovic G, Gyaneshwar P, Rolfe MD, Thompson A, Hinton JC, Buck M  Identification of a new member of the phage shock protein response in Escherichia coli, the phage shock protein G (PspG).  J Biol Chem. 2004 Dec 31;279(53):55707-14. Epub 2004 Oct 13.  PMID 15485810
[ 4 ]Jovanovic G, Lloyd LJ, Stumpf MP, Mayhew AJ, Buck M  Induction and function of the phage-shock-protein (Psp) extracytoplasmic stress response in Escherichia coli.  J Biol Chem. 2006 May 17  PMID 16709570
[ 5 ]Trotochaud AE, Wassarman KM  6S RNA regulation of pspF transcription leads to altered cell survival at high pH.  J Bacteriol. 2006 Jun;188(11):3936-43.  PMID 16707685
[ 1 ]Brissette JL, Weiner L, Ripmaster TL, Model P  Characterization and sequence of the Escherichia coli stress-induced psp operon.  J Mol Biol. 1991 Jul 5;220(1):35-48.  PMID 1712397
[ 2 ]Jovanovic G, Weiner L, Model P  Identification, nucleotide sequence, and characterization of PspF, the transcriptional activator of the Escherichia coli stress-induced psp operon.  J Bacteriol. 1996 Apr;178(7):1936-45.  PMID 8606168
[ 3 ]Lloyd LJ, Jones SE, Jovanovic G, Gyaneshwar P, Rolfe MD, Thompson A, Hinton JC, Buck M  Identification of a new member of the phage shock protein response in Escherichia coli, the phage shock protein G (PspG).  J Biol Chem. 2004 Dec 31;279(53):55707-14. Epub 2004 Oct 13.  PMID 15485810
[ 4 ]Jovanovic G, Lloyd LJ, Stumpf MP, Mayhew AJ, Buck M  Induction and function of the phage-shock-protein (Psp) extracytoplasmic stress response in Escherichia coli.  J Biol Chem. 2006 May 17  PMID 16709570
[ 5 ]Trotochaud AE, Wassarman KM  6S RNA regulation of pspF transcription leads to altered cell survival at high pH.  J Bacteriol. 2006 Jun;188(11):3936-43.  PMID 16707685
[ 1 ]Brissette JL, Weiner L, Ripmaster TL, Model P  Characterization and sequence of the Escherichia coli stress-induced psp operon.  J Mol Biol. 1991 Jul 5;220(1):35-48.  PMID 1712397
[ 2 ]Jovanovic G, Weiner L, Model P  Identification, nucleotide sequence, and characterization of PspF, the transcriptional activator of the Escherichia coli stress-induced psp operon.  J Bacteriol. 1996 Apr;178(7):1936-45.  PMID 8606168
[ 3 ]Lloyd LJ, Jones SE, Jovanovic G, Gyaneshwar P, Rolfe MD, Thompson A, Hinton JC, Buck M  Identification of a new member of the phage shock protein response in Escherichia coli, the phage shock protein G (PspG).  J Biol Chem. 2004 Dec 31;279(53):55707-14. Epub 2004 Oct 13.  PMID 15485810
[ 4 ]Jovanovic G, Lloyd LJ, Stumpf MP, Mayhew AJ, Buck M  Induction and function of the phage-shock-protein (Psp) extracytoplasmic stress response in Escherichia coli.  J Biol Chem. 2006 May 17  PMID 16709570
[ 5 ]Trotochaud AE, Wassarman KM  6S RNA regulation of pspF transcription leads to altered cell survival at high pH.  J Bacteriol. 2006 Jun;188(11):3936-43.  PMID 16707685
Gene Ontology TermGO:0006950: response to stress (biological_process)
GO:0006950: response to stress (biological_process)
GO:0006950: response to stress (biological_process)
GO:0006950: response to stress (biological_process)
GO:0006950: response to stress (biological_process)
GO:0006950: response to stress (biological_process)
GO:0006950: response to stress (biological_process)
GO:0006950: response to stress (biological_process)
GO:0006950: response to stress (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
phage shock protein PspApspAYESTIGR02977 (HMM): phage shock protein A
TIGR02977 (HMM): phage shock protein A
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspApspAYESTIGR02977 (HMM): phage shock protein A
TIGR02977 (HMM): phage shock protein A
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspApspAYESTIGR02977 (HMM): phage shock protein A
TIGR02977 (HMM): phage shock protein A
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspBpspBYESTIGR02976 (HMM): phage shock protein B
TIGR02976 (HMM): phage shock protein B
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspBpspBYESTIGR02976 (HMM): phage shock protein B
TIGR02976 (HMM): phage shock protein B
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspBpspBYESTIGR02976 (HMM): phage shock protein B
TIGR02976 (HMM): phage shock protein B
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspCpspCYESTIGR02978 (HMM): phage shock protein C
TIGR02978 (HMM): phage shock protein C
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspCpspCYESTIGR02978 (HMM): phage shock protein C
TIGR02978 (HMM): phage shock protein C
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspCpspCYESTIGR02978 (HMM): phage shock protein C
TIGR02978 (HMM): phage shock protein C
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspDpspDNOTIGR02979 (HMM): phage shock protein PspD
TIGR02979 (HMM): phage shock protein PspD
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspDpspDNOTIGR02979 (HMM): phage shock protein PspD
TIGR02979 (HMM): phage shock protein PspD
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspDpspDNOTIGR02979 (HMM): phage shock protein PspD
TIGR02979 (HMM): phage shock protein PspD
GO:0006950: response to stress
GO:0006950: response to stress
rhodanese PspEpspENOTIGR02981 (HMM): phage shock operon rhodanese PspE
TIGR02981 (HMM): phage shock operon rhodanese PspE
GO:0006950: response to stress
GO:0006950: response to stress
rhodanese PspEpspENOTIGR02981 (HMM): phage shock operon rhodanese PspE
TIGR02981 (HMM): phage shock operon rhodanese PspE
GO:0006950: response to stress
GO:0006950: response to stress
rhodanese PspEpspENOTIGR02981 (HMM): phage shock operon rhodanese PspE
TIGR02981 (HMM): phage shock operon rhodanese PspE
GO:0006950: response to stress
GO:0006950: response to stress
signa-54-dependent activagtor PspFpspFYESTIGR02974 (HMM): psp operon transcriptional activator
TIGR02974 (HMM): psp operon transcriptional activator
GO:0006950: response to stress
GO:0006950: response to stress
signa-54-dependent activagtor PspFpspFYESTIGR02974 (HMM): psp operon transcriptional activator
TIGR02974 (HMM): psp operon transcriptional activator
GO:0006950: response to stress
GO:0006950: response to stress
signa-54-dependent activagtor PspFpspFYESTIGR02974 (HMM): psp operon transcriptional activator
TIGR02974 (HMM): psp operon transcriptional activator
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspG (YjbO)pspGNOTIGR02975 (HMM): phage shock protein G
TIGR02975 (HMM): phage shock protein G
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspG (YjbO)pspGNOTIGR02975 (HMM): phage shock protein G
TIGR02975 (HMM): phage shock protein G
GO:0006950: response to stress
GO:0006950: response to stress
phage shock protein PspG (YjbO)pspGNOTIGR02975 (HMM): phage shock protein G
TIGR02975 (HMM): phage shock protein G
GO:0006950: response to stress
GO:0006950: response to stress

Parent Properties
AccessionName
GenProp0074virulence
GenProp0462response to stress
GenProp0074virulence
GenProp0462response to stress
GenProp0074virulence
GenProp0462response to stress


Sibling Properties
AccessionName
GenProp0032pathogen of plants
GenProp0049spore formation
GenProp0051urease
GenProp0052type III secretion
GenProp0056type IV pilus
GenProp0062capsule
GenProp0154intrinsic pathogen of animals
GenProp0707botulinum toxin system
GenProp0849quorum-sensing, Bacillus PlcR-PapR system
GenProp0211tmRNA trans-translation system
GenProp04826S RNA (eubacterial RNA polymerase regulator)