| Description | The ribulose monophosphate pathway consists of two enzyme, 3-hexulose-6-phosphate synthase (HPS) and 6-phospho-3-hexuloisomerase (PHI). In one direction, this pathway removes the toxic metabolite formaldehyde by assimilation. In the other direction, in certain species lacking the complete pentose phosphate pathway, this pathway produces consumes fructose 6-phosphate and releases formaldehyde in order to produce ribulose-5-phosphate, essential for nucleotide biosynthesis. The two enzymes may occur as a fusion protein, as in Thermococcus kodakaraensis. |
| Literature References | [ 1 ]Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis. J Bacteriol. 2006 Jul;188(13):4698-704. PMID 16788179
[ 2 ]Grochowski LL, Xu H, White RH Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway. J Bacteriol. 2005 Nov;187(21):7382-9. PMID 16237021
[ 3 ]Yurimoto H, Hirai R, Matsuno N, Yasueda H, Kato N, Sakai Y HxlR, a member of the DUF24 protein family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis. Mol Microbiol. 2005 Jul;57(2):511-9. PMID 15978081
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