Genome Property Definition Page

AccessionGenProp0676
Namealkylhydroperoxide reductase AhpCF (peroxiredoxin)
TypeSYSTEM
DescriptionThis two-gene peroxiredoxin consists of ahpC and ahpF, ususally as tandem genes in an apparent operon. Peroxiredoxin detoxifies alkyl hydroperoxides by catalyzing the oxidation of an active site cysteine (on AhpC) to a sulfenic acid. This subsequently becomes a disulfide which is then resolved by reduction. AhpF contains an FAD-binding domain along with a NAD(P)H binding domain (PF07992).
JCVI RoleDetoxification
Parent PropertyGenProp0213: Resistance to Reactive Oxygen Species (ROS)
GenProp0303: detoxification
Literature References
[ 1 ]Rocha ER, Smith CJ  Role of the alkyl hydroperoxide reductase (ahpCF) gene in oxidative stress defense of the obligate Anaerobe bacteroides fragilis.  J Bacteriol. 1999 Sep;181(18):5701-10.  PMID 10482511
Gene Ontology TermGO:0006800: oxygen and reactive oxygen species metabolic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
subunit CahpCYESTIGR03137 (HMM): peroxiredoxinGO:0006800: oxygen and reactive oxygen species metabolic process
subunit FahpFYESTIGR03140 (HMM): alkyl hydroperoxide reductase subunit F
TIGR03143 (HMM): putative alkyl hydroperoxide reductase F subunit
GO:0006800: oxygen and reactive oxygen species metabolic process
GO:0006800: oxygen and reactive oxygen species metabolic process

Parent Properties
AccessionName
GenProp0213Resistance to Reactive Oxygen Species (ROS)
GenProp0303detoxification


Sibling Properties
AccessionName
GenProp0151resistance to mercury
GenProp0213Resistance to Reactive Oxygen Species (ROS)
GenProp0474arsenical resistance system
GenProp0488superoxide dismutase, nickel-type
GenProp0562formaldehyde detoxification, glutathione-dependent
GenProp0673ribulose monophosphate pathway
GenProp0744glyoxalase pathway, glutathione dependent