Genome Property Definition Page

AccessionGenProp0677
Namequeuosine (Q-tRNA) biosynthesis from preQ0
TypePATHWAY
DescriptionpreQ0 (7-cyano-7-deazaguanine) is the last common intermediate in the biosyntheses of queuosine (in bacteria and eukarya) and archaeosine (in archaea). preQ0 is converted to queuosine by the action of at least four enzymes, two reductases, a tRNA(GUN) transferase and an adenosylmethionine ribosyl transferase-isomerase.
JCVI RoletRNA and rRNA base modification
Parent PropertyGenProp0819: RNA metabolism
GenProp0819: RNA metabolism
GenProp0819: RNA metabolism
Literature References
[ 1 ]Van Lanen SG, Reader JS, Swairjo MA, de Crecy-Lagard V, Lee B, Iwata-Reuyl D  From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold.  Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4264-9. Epub 2005 Mar 14.  PMID 15767583
[ 2 ]Phillips G, El Yacoubi B, Lyons B, Alvarez S, Iwata-Reuyl D, de Crecy-Lagard V  Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I.  J Bacteriol. 2008 Dec;190(24):7876-84. Epub 2008 Oct 17.  PMID 18931107
[ 3 ]Miles ZD, McCarty RM, Molnar G, Bandarian V  Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification.  Proc Natl Acad Sci U S A. 2011 May 3;108(18):7368-72.  PMID 21502530
[ 1 ]Van Lanen SG, Reader JS, Swairjo MA, de Crecy-Lagard V, Lee B, Iwata-Reuyl D  From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold.  Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4264-9. Epub 2005 Mar 14.  PMID 15767583
[ 2 ]Phillips G, El Yacoubi B, Lyons B, Alvarez S, Iwata-Reuyl D, de Crecy-Lagard V  Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I.  J Bacteriol. 2008 Dec;190(24):7876-84. Epub 2008 Oct 17.  PMID 18931107
[ 3 ]Miles ZD, McCarty RM, Molnar G, Bandarian V  Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification.  Proc Natl Acad Sci U S A. 2011 May 3;108(18):7368-72.  PMID 21502530
[ 1 ]Van Lanen SG, Reader JS, Swairjo MA, de Crecy-Lagard V, Lee B, Iwata-Reuyl D  From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold.  Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4264-9. Epub 2005 Mar 14.  PMID 15767583
[ 2 ]Phillips G, El Yacoubi B, Lyons B, Alvarez S, Iwata-Reuyl D, de Crecy-Lagard V  Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I.  J Bacteriol. 2008 Dec;190(24):7876-84. Epub 2008 Oct 17.  PMID 18931107
[ 3 ]Miles ZD, McCarty RM, Molnar G, Bandarian V  Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification.  Proc Natl Acad Sci U S A. 2011 May 3;108(18):7368-72.  PMID 21502530
Gene Ontology TermGO:0008616: queuosine biosynthetic process (biological_process)
GO:0008616: queuosine biosynthetic process (biological_process)
GO:0008616: queuosine biosynthetic process (biological_process)
GO:0008616: queuosine biosynthetic process (biological_process)
GO:0008616: queuosine biosynthetic process (biological_process)
GO:0008616: queuosine biosynthetic process (biological_process)
GO:0008616: queuosine biosynthetic process (biological_process)
GO:0008616: queuosine biosynthetic process (biological_process)
GO:0008616: queuosine biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
preQ1 tRNA transferaseQ1transYESTIGR00430 (HMM): tRNA-guanine transglycosylaseGO:0008616: queuosine biosynthetic process
preQ1 tRNA transferaseQ1transYESTIGR00430 (HMM): tRNA-guanine transglycosylaseGO:0008616: queuosine biosynthetic process
preQ1 tRNA transferaseQ1transYESTIGR00430 (HMM): tRNA-guanine transglycosylaseGO:0008616: queuosine biosynthetic process
queuosine synthetase oxo-queuosine reductaseQsynthNO
queuosine synthetase oxo-queuosine reductaseQsynthNO
queuosine synthetase oxo-queuosine reductaseQsynthNO
preQ1-tRNA adenosyl methionine ribosyl transferase isomeraseQueAYESTIGR00113 (HMM): S-adenosylmethionine:tRNA ribosyltransferase-isomeraseGO:0008616: queuosine biosynthetic process
preQ1-tRNA adenosyl methionine ribosyl transferase isomeraseQueAYESTIGR00113 (HMM): S-adenosylmethionine:tRNA ribosyltransferase-isomeraseGO:0008616: queuosine biosynthetic process
preQ1-tRNA adenosyl methionine ribosyl transferase isomeraseQueAYESTIGR00113 (HMM): S-adenosylmethionine:tRNA ribosyltransferase-isomeraseGO:0008616: queuosine biosynthetic process
preQ0 reductaseQueFYESTIGR03138 (HMM): queuine synthase
TIGR03139 (HMM): 7-cyano-7-deazaguanine reductase
GO:0008616: queuosine biosynthetic process
GO:0008616: queuosine biosynthetic process
preQ0 reductaseQueFYESTIGR03138 (HMM): queuine synthase
TIGR03139 (HMM): 7-cyano-7-deazaguanine reductase
GO:0008616: queuosine biosynthetic process
GO:0008616: queuosine biosynthetic process
preQ0 reductaseQueFYESTIGR03138 (HMM): queuine synthase
TIGR03139 (HMM): 7-cyano-7-deazaguanine reductase
GO:0008616: queuosine biosynthetic process
GO:0008616: queuosine biosynthetic process
epoxyqueuosine reductaseQueGYESTIGR00276 (HMM): epoxyqueuosine reductaseGO:0008616: queuosine biosynthetic process
epoxyqueuosine reductaseQueGYESTIGR00276 (HMM): epoxyqueuosine reductaseGO:0008616: queuosine biosynthetic process
epoxyqueuosine reductaseQueGYESTIGR00276 (HMM): epoxyqueuosine reductaseGO:0008616: queuosine biosynthetic process

Parent Properties
AccessionName
GenProp0819RNA metabolism
GenProp0819RNA metabolism
GenProp0819RNA metabolism


Sibling Properties
AccessionName
GenProp0258tRNA aminoacylation
GenProp0262RNA polymerase, bacterial
GenProp04826S RNA (eubacterial RNA polymerase regulator)
GenProp0692selenouridine-containing tRNA
GenProp0704tRNA U34 carboxymethylaminomethyl modification
GenProp0898RNA ligase/unknown protein pair
GenProp0948RNA repair, Hen1/Pnkp system
GenProp1060tRNA N6-threonylcarbamoyladenosine modification
GenProp1077tRNA(Pro) cmo5UGG modification
GenProp108216S rRNA C1402 m(4)Cm modification