Genome Property Definition Page

Nameallantoin catabolism to glyoxalate and urea
Description(S)-allantoin ([(4S)-2,5-dioxoimidazolidin-4-yl]urea) is a breakdown product of urate and may be obtained by an endogenous urate catabolism pathway or by transport from the environment. Catabolism of allantoate consists of a three-step pathway resulting in glyoxalate. This is further processed to tartronate semi-aldehyde (2-hydroxy-3-oxopropanoate) and subsequently to either phyosphoglycerate or glycoaldehyde (in the pathway to the pyridoxine component of vitamin B6). Since many pathways result in glyoxalate, this genome property terminates at that compound although the downsream enzymes may be grouped into apparent operons in many organisms (i.e. E. coli). Degradation of allantoin results in the production of two molecules of urea which may be excreted or used as a source of ammonia in urease-containing organisms.
JCVI RoleOther
Parent PropertyGenProp0142: catabolism
Literature References
[ 1 ]Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J  Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.  J Bacteriol. 1999 Dec;181(24):7479-84.  PMID 10601204
Gene Ontology TermGO:0009442: allantoin assimilation pathway (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
source of (S)-allantoinall-inNOTIGR00800 (HMM-CLUST): NCS1 nucleoside transporter familyGenProp0688 (GENPROP): urate catabolism to allantoin
GO:0009442: allantoin assimilation pathway
GO:0009442: allantoin assimilation pathway
ureidoglycolate lyase ( (HMM): ureidoglycolate lyaseGO:0009442: allantoin assimilation pathway
allantoinase ( (HMM): allantoinaseGO:0009442: allantoin assimilation pathway
allantoin hydrolysis, finalallC-fNOTIGR02961 (HMM): allantoicaseGO:0009442: allantoin assimilation pathway
allantoin hydrolysis, initialallC-iYESTIGR02961 (HMM): allantoicase
TIGR03176 (HMM): allantoate amidohydrolase
GO:0009442: allantoin assimilation pathway
GO:0009442: allantoin assimilation pathway
cupin domain protein, unknown functionallXNOTIGR03214 (HMM): putative allantoin catabolism proteinGO:0009442: allantoin assimilation pathway

Parent Properties

Sibling Properties
GenProp0055polyhydroxyalkanoic acids
GenProp0141galactose-6-phosphate degradation via tagatose-6-phosphate
GenProp0156cyanophycin-like storage polymers
GenProp0168glycogen system
GenProp0210phenylacetic acid catabolism
GenProp02314-hydroxyphenylacetate degradation
GenProp0233GABA utilization
GenProp02382-aminoethylphosphonate catabolism to acetaldehyde
GenProp0239propionyl-CoA catabolism
GenProp0241phosphonate catabolism
GenProp0271trehalose utilization
GenProp0272pyruvate fermentation to acetoin
GenProp0273protocatechuate degradation to beta-ketoadipate
GenProp0283beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA
GenProp0294ethanolamine catabolism to acetaldehyde
GenProp0457rhamnose catabolism
GenProp0458fucose catabolism
GenProp0461utilization of deoxynucleosides
GenProp0653ectoine catabolism
GenProp0674malonate decarboxylase
GenProp0687allantoin catabolism to oxamate and carbamoyl-phosphate
GenProp0688urate catabolism to allantoin
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp0700purine catabolism via urate, xanthine and allantoin
GenProp0702benzoyl-CoA reductase
GenProp07034-hydroxybenzoyl-CoA reductase
GenProp0706cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway
GenProp0708catechol meta-cleavage pathway
GenProp0709benzoate catabolism BoxABC pathway
GenProp0711catechol ortho-cleavage upper pathway
GenProp0714galactarate utilization via tartronate semi-aldehyde
GenProp0715galactarate utilization via 2-oxoglutarate semialdehyde
GenProp0716glucarate utilization via tartronate semi-aldehyde
GenProp0717glucarate utilization via 2-oxoglutarate semialdehyde
GenProp0718oxalate degradation
GenProp0734amino acid catabolism
GenProp0749choline sulfate utilization
GenProp0760putrescine degradation to GABA via gamma-glutamylation
GenProp0763nicotinate fermentation to pyruvate and propionate
GenProp0813pyrimidine utilization operon, RutABCDEFGR
GenProp0902quinohemoprotein amine dehydrogenase
GenProp1071myo-inositol catabolism
GenProp1072cyanase system
GenProp1076choline TMA-lyase system