Genome Property Definition Page

AccessionGenProp0688
Nameurate catabolism to allantoin
TypePATHWAY
DescriptionUrate is the product of xanthine catabolism by either the xanthine dehydrogenase complex (GenProp0640) or xanthine oxidase. The purine ring system of urate is oxidized by uricase (urate oxidase) and the 6-membered ring is opened by hydroxyisourate hydrolase. The hydrolase may be unnecessary in some organisms as the hydroxyisourate will hydrolyze spontaneously, albeit an a slow rate. The resulting product (OHCU) then spontaneously decarboxylates, resulting in a mixture of (S)- and (R)-allantoin. For further catabolism, generally only (S)-allantoin is processed, so allantoin racemace is also typically found. An OHCU carboxylase has been discovered in Mus musculus which does have homologs in prokaryotes.
JCVI RoleOther
Parent PropertyGenProp0142: catabolism
Literature References
[ 1 ]Hennebry SC, Law RH, Richardson SJ, Buckle AM, Whisstock JC  The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase.  J Mol Biol. 2006 Jun 23;359(5):1389-99. Epub 2006 May 11.  PMID 16787778
[ 2 ]Saeed HM, Abdel-Fattah YR, Berekaa MM, Gohar YM, Elbaz MA  Identification, cloning and expression of Pseudomonas aeruginosa Ps-x putative urate oxidase gene in Escherichia coli.  Pol J Microbiol. 2004;53(4):227-36.  PMID 15790071
[ 3 ]Ramazzina I, Folli C, Secchi A, Berni R, Percudani R  Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes.  Nat Chem Biol. 2006 Mar;2(3):144-8. Epub 2006 Feb 5.  PMID 16462750
Gene Ontology TermGO:0019628: urate catabolic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
hypothetical urate oxidase non-orthologous displacementshyp_uoxNOGENE_CLUST (MANUAL)
urate oxidase (uricase, 1.7.3.3)uoxYESPF01014 (HMM): uricaseGO:0019628: urate catabolic process
OHCU decarboxylaseuraDYESTIGR03164 (HMM): OHCU decarboxylase
TIGR03180 (HMM): OHCU decarboxylase
GO:0019628: urate catabolic process
GO:0019628: urate catabolic process
hydroxyisourate hydrolase (3.5.2.17)uraHYESTIGR02962 (HMM): hydroxyisourate hydrolaseGO:0019628: urate catabolic process
uraD N-terminal domain/upstream proteinuraXNOTIGR03212 (HMM): putative urate catabolism proteinGO:0019628: urate catabolic process

Parent Properties
AccessionName
GenProp0142catabolism


Sibling Properties
AccessionName
GenProp0055polyhydroxyalkanoic acids
GenProp0141galactose-6-phosphate degradation via tagatose-6-phosphate
GenProp0156cyanophycin-like storage polymers
GenProp0168glycogen system
GenProp0210phenylacetic acid catabolism
GenProp02314-hydroxyphenylacetate degradation
GenProp0233GABA utilization
GenProp02382-aminoethylphosphonate catabolism to acetaldehyde
GenProp0239propionyl-CoA catabolism
GenProp0241phosphonate catabolism
GenProp0271trehalose utilization
GenProp0272pyruvate fermentation to acetoin
GenProp0273protocatechuate degradation to beta-ketoadipate
GenProp0283beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA
GenProp0294ethanolamine catabolism to acetaldehyde
GenProp0457rhamnose catabolism
GenProp0458fucose catabolism
GenProp0461utilization of deoxynucleosides
GenProp0653ectoine catabolism
GenProp0674malonate decarboxylase
GenProp0686allantoin catabolism to glyoxalate and urea
GenProp0687allantoin catabolism to oxamate and carbamoyl-phosphate
GenProp0691glycolysis
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp0700purine catabolism via urate, xanthine and allantoin
GenProp0702benzoyl-CoA reductase
GenProp07034-hydroxybenzoyl-CoA reductase
GenProp0706cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway
GenProp0708catechol meta-cleavage pathway
GenProp0709benzoate catabolism BoxABC pathway
GenProp0711catechol ortho-cleavage upper pathway
GenProp0714galactarate utilization via tartronate semi-aldehyde
GenProp0715galactarate utilization via 2-oxoglutarate semialdehyde
GenProp0716glucarate utilization via tartronate semi-aldehyde
GenProp0717glucarate utilization via 2-oxoglutarate semialdehyde
GenProp0718oxalate degradation
GenProp0734amino acid catabolism
GenProp0749choline sulfate utilization
GenProp0760putrescine degradation to GABA via gamma-glutamylation
GenProp0763nicotinate fermentation to pyruvate and propionate
GenProp0813pyrimidine utilization operon, RutABCDEFGR
GenProp0902quinohemoprotein amine dehydrogenase
GenProp1071myo-inositol catabolism
GenProp1072cyanase system
GenProp1076choline TMA-lyase system