Genome Property Definition Page

AccessionGenProp0707
Namebotulinum toxin system
TypeSYSTEM
DescriptionClostridium botulinum contains a virulence cassette encoding a potent neurotoxin called BoNT. Also found in this operon are several hemagglutinin proteins and a regulatory sigma-70 gene.
JCVI RolePathogenesis
Parent PropertyGenProp0074: virulence

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
neurotoxin componentBoNTYESPF07951 (HMM): Clostridium neurotoxin, C-terminal receptor binding
PF07952 (HMM): Clostridium neurotoxin, Translocation domain
Sigma-70 factor regulatorBotRYESTIGR03209 (HMM): transcriptional regulator BotR, P-21
haemagglutinin HA17HA-17YESPF05588 (HMM): Clostridium botulinum HA-17 protein
haemagglutinin HA33HA-33YESPF00652 (HMM): ricin-type beta-trefoil lectin domain
haemagglutinin HA70HA-70YESPF03505 (HMM): Clostridium enterotoxin
non-toxin, non-haemaglutinin componentntnhYESPF08470 (HMM): nontoxic nonhaemagglutinin C-terminal

Parent Properties
AccessionName
GenProp0074virulence


Sibling Properties
AccessionName
GenProp0032pathogen of plants
GenProp0049spore formation
GenProp0051urease
GenProp0052type III secretion
GenProp0056type IV pilus
GenProp0062capsule
GenProp0154intrinsic pathogen of animals
GenProp0648phage shock protein regulon
GenProp0849quorum-sensing, Bacillus PlcR-PapR system