Genome Property Definition Page

AccessionGenProp0718
Nameoxalate degradation
TypePATHWAY
DescriptionA two-enzyme pathway degrades oxalate, a toxic metabolite. Formyl-CoA transferase transfers coenzyme A from formyl-CoA to oxalate, leaving formate. Oxalyl-CoA decarboxylase, a TPP-containing enzyme, removes C02 to regenerate formyl-CoA. The net result is conversion of oxalate to formate and CO2. This system was originally described in Oxalobacter formigenes from the human gut, and is found in a number of other gut bacteria.
JCVI RoleDetoxification
Parent PropertyGenProp0142: catabolism
Literature References
[ 1 ]Azcarate-Peril MA, Bruno-Barcena JM, Hassan HM, Klaenhammer TR  Transcriptional and functional analysis of oxalyl-coenzyme A (CoA) decarboxylase and formyl-CoA transferase genes from Lactobacillus acidophilus.  Appl Environ Microbiol. 2006 Mar;72(3):1891-9.  PMID 16517636
[ 2 ]Gruez A, Roig-Zamboni V, Valencia C, Campanacci V, Cambillau C  The crystal structure of the Escherichia coli YfdW gene product reveals a new fold of two interlaced rings identifying a wide family of CoA transferases.  J Biol Chem. 2003 Sep 5;278(36):34582-6. Epub 2003 Jul 3.  PMID 12844490

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
formyl-CoA transferase1_frcYESTIGR03253 (HMM): formyl-CoA transferase
oxalyl-CoA decarboxylase2_oxcYESTIGR03254 (HMM): oxalyl-CoA decarboxylase

Parent Properties
AccessionName
GenProp0142catabolism


Sibling Properties
AccessionName
GenProp0055polyhydroxyalkanoic acids
GenProp0141galactose-6-phosphate degradation via tagatose-6-phosphate
GenProp0156cyanophycin-like storage polymers
GenProp0168glycogen system
GenProp0210phenylacetic acid catabolism
GenProp02314-hydroxyphenylacetate degradation
GenProp0233GABA utilization
GenProp02382-aminoethylphosphonate catabolism to acetaldehyde
GenProp0239propionyl-CoA catabolism
GenProp0241phosphonate catabolism
GenProp0271trehalose utilization
GenProp0272pyruvate fermentation to acetoin
GenProp0273protocatechuate degradation to beta-ketoadipate
GenProp0283beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA
GenProp0294ethanolamine catabolism to acetaldehyde
GenProp0457rhamnose catabolism
GenProp0458fucose catabolism
GenProp0461utilization of deoxynucleosides
GenProp0653ectoine catabolism
GenProp0674malonate decarboxylase
GenProp0686allantoin catabolism to glyoxalate and urea
GenProp0687allantoin catabolism to oxamate and carbamoyl-phosphate
GenProp0688urate catabolism to allantoin
GenProp0691glycolysis
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp0700purine catabolism via urate, xanthine and allantoin
GenProp0702benzoyl-CoA reductase
GenProp07034-hydroxybenzoyl-CoA reductase
GenProp0706cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway
GenProp0708catechol meta-cleavage pathway
GenProp0709benzoate catabolism BoxABC pathway
GenProp0711catechol ortho-cleavage upper pathway
GenProp0714galactarate utilization via tartronate semi-aldehyde
GenProp0715galactarate utilization via 2-oxoglutarate semialdehyde
GenProp0716glucarate utilization via tartronate semi-aldehyde
GenProp0717glucarate utilization via 2-oxoglutarate semialdehyde
GenProp0734amino acid catabolism
GenProp0749choline sulfate utilization
GenProp0760putrescine degradation to GABA via gamma-glutamylation
GenProp0763nicotinate fermentation to pyruvate and propionate
GenProp0813pyrimidine utilization operon, RutABCDEFGR
GenProp0902quinohemoprotein amine dehydrogenase
GenProp1071myo-inositol catabolism
GenProp1072cyanase system
GenProp1076choline TMA-lyase system