Genome Property Definition Page
| Accession | GenProp0719 |
| Name | methyl-coenzyme M reductase |
| Type | SYSTEM |
| Description | Methyl-coenzyme M reductase is a nickel-containing, alpha2/beta2/gamma2 hexameric enzyme that catalyzes the final step in methanogenesis. This enzyme has several novel post-translational modifications; it is found in methanogenic archaea, many of which are hyperthermophiles. Many archaea have two versions of this enzyme. It appears that some Archaea are methanotrophic; homologous proteins act in the anaerobic oxidation of methane rather than in methanogenesis. |
| JCVI Role | Methanogenesis |
| Parent Property | GenProp0011: methanogenesis GenProp0031: methane utilization |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| methyl-coenzyme M reductase, alpha subunit | alpha | YES | TIGR03256 (HMM): methyl-coenzyme M reductase, alpha subunit | |
| methyl-coenzyme M reductase, beta subunit | beta | YES | TIGR03257 (HMM): methyl-coenzyme M reductase, beta subunit | |
| methyl-coenzyme M reductase, gamma subunit | gamma | YES | TIGR03259 (HMM): methyl-coenzyme M reductase, gamma subunit | |
| methyl coenzyme M reductase system, component A2 | mcr_A2 | YES | TIGR03269 (HMM): methyl coenzyme M reductase system, component A2 | |
| methyl-coenzyme M reductase I operon protein C | oper_C | YES | TIGR03264 (HMM): methyl-coenzyme M reductase I operon protein C | |
| methyl-coenzyme M reductase operon protein D | oper_D | YES | TIGR03260 (HMM): methyl-coenzyme M reductase operon protein D |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0011 | methanogenesis |
| GenProp0031 | methane utilization |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0288 | tetrahydromethanopterin S-methyltransferase complex |
| GenProp0722 | methanogenesis marker set |
| GenProp0666 | membrane-associated monooxygenase (methane/ammonia) |