Genome Property Definition Page

Namehydrogenase, nickel and F420-dependent
DescriptionThis nickel hydrogenase reduces coenzyme F420 and is found exclusively in methanogenic archaea, but not universally. It is lacking from at least four Methanosarcinales.
Parent PropertyGenProp0070: energy metabolism
Literature References
[ 1 ]Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT  Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H.  Biochemistry. 1990 Aug 7;29(31):7237-44.  PMID 2207102

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
coenzyme F420 hydrogenase, subunit alphafrhAYESTIGR03295 (HMM): coenzyme F420 hydrogenase, subunit alpha
coenzyme F420 hydrogenase, subunit betafrhBYESTIGR03289 (HMM): coenzyme F420 hydrogenase, subunit beta
coenzyme F420 hydrogenase, maturation proteasefrhDYESTIGR00130 (HMM): coenzyme F420-reducing hydrogenase, FrhD protein
coenzyme F420 hydrogenase, subunit gammafrhGYESTIGR03294 (HMM): coenzyme F420 hydrogenase, subunit gamma

Parent Properties
GenProp0070energy metabolism

Sibling Properties
GenProp0023glyoxylate shunt
GenProp0033TCA cycle
GenProp0120pentose phosphate cycle
GenProp0131electron transport
GenProp0243ATP synthases
GenProp0459D-xylose utilization (conversion to D-xylulose-5-phosphate)
GenProp0468Entner-Doudoroff pathway
GenProp0473arsenite oxidase
GenProp0611aerobic respiration
GenProp0636respiratory nitrate reductase
GenProp0637anaerobic dimethyl sulfoxide reductase
GenProp0638trimethylamine N-oxide reductase system
GenProp0682formate-dependent nitrite reductase, seven-gene type
GenProp0683cytochrome c nitrite reductase NrfHA
GenProp0695cytochrome b558/566
GenProp0737anaerobic glycerol-3-phosphate dehydrogenase complex
GenProp0755pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating
GenProp0756fumarate reductase complex
GenProp0764DMSO reductase family type II enzyme
GenProp08412-oxoacid:ferredoxin oxidoreductase
GenProp0856bacterio-opsin system
GenProp0914hydrogenase, [FeFe]-dependent
GenProp0915hydrogenase, mono-iron type
GenProp1089B12-dependent trimeric diol/glycerol dehydratase