Genome Property Definition Page

AccessionGenProp0724
Namephosphonoacetaldehyde biosynthesis from phosphoenolpyruvate
TypePATHWAY
DescriptionPhosphonacetaldehyde is a precursor of natural products, lipids and polysaccharides containing phosphonates (C-P linkages). Often this is converted by an aminotransferase to the most common naturally occuring phosphonate, 2-aminoethylphosphonate.
JCVI RolePhosphorus compounds
Parent PropertyGenProp0063: biosynthesis
GenProp0077: natural products biosynthesis
GenProp0242: phosphorus metabolism
Literature References
[ 1 ]Hidaka T, Hidaka M, Seto H  Studies on the biosynthesis of bialaphos (SF-1293). 14. Nucleotide sequence of phosphoenolpyruvate phosphomutase gene isolated from a bialaphos producing organism, Streptomyces hygroscopicus, and its expression in Streptomyces lividans.  J Antibiot (Tokyo). 1992 Dec;45(12):1977-80.  PMID 1337066
[ 2 ]Schwartz D, Recktenwald J, Pelzer S, Wohlleben W  Isolation and characterization of the PEP-phosphomutase and the phosphonopyruvate decarboxylase genes from the phosphinothricin tripeptide producer Streptomyces viridochromogenes Tu494.  FEMS Microbiol Lett. 1998 Jun 15;163(2):149-57.  PMID 9673017
[ 3 ]Coyne MJ, Kalka-Moll W, Tzianabos AO, Kasper DL, Comstock LE  Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci.  Infect Immun. 2000 Nov;68(11):6176-81.  PMID 11035722
Gene Ontology TermGO:0006796: phosphate-containing compound metabolic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
PEP phosphomutaseAepXYESTIGR02320 (HMM): phosphoenolpyruvate mutaseGO:0006796: phosphate-containing compound metabolic process
phosphonopyruvate decarboxylaseAepYYESTIGR03297 (HMM): phosphonopyruvate decarboxylaseGO:0006796: phosphate-containing compound metabolic process
2-aminophosphonate transaminaseAepZNOTIGR03301 (SUBFAMILY): 2-aminoethylphosphonate aminotransferase
TIGR02326 (SUBFAM-EX): 2-aminoethylphosphonate--pyruvate transaminase
GO:0006796: phosphate-containing compound metabolic process
proximal marker of exopolysaccharide biosynthesisEPSNOPF01943 (HMM-CLUST): polysaccharide biosynthesis protein
proximal marker of lipid biosynthesisLipidNOPF01066 (HMM-CLUST): CDP-alcohol phosphatidyltransferase
proximal marker of natural products biosynthesisNatPrdNOTIGR01787 (HMM-CLUST): squalene/oxidosqualene cyclases
proximal nucleotidyltransferase domainnuc-trNOPF01467 (HMM-CLUST): cytidylyltransferase
PF00483 (HMM-CLUST): nucleotidyl transferase
PF02348 (HMM-CLUST): cytidylyltransferase
proximal oxidoreductases/oxygenasesoxidoNOPF00465 (HMM-CLUST): alcohol dehydrogenase, iron-containing
TIGR03250 (HMM-CLUST): putative phosphonoacetaldehyde dehydrogenase
PF03171 (HMM-CLUST): oxidoreductase, 2OG-Fe(II) oxygenase family

Parent Properties
AccessionName
GenProp0063biosynthesis
GenProp0077natural products biosynthesis
GenProp0242phosphorus metabolism


Sibling Properties
AccessionName
GenProp0077natural products biosynthesis
GenProp0126amino acid biosynthesis
GenProp0184cofactor biosynthesis
GenProp0185nucleotide biosynthesis
GenProp0186storage and structural polymer biosynthesis
GenProp0197protein biosynthesis
GenProp0219spermidine biosynthesis from arginine (via agmatine)
GenProp0267osmolyte biosynthesis
GenProp0641spermidine biosynthesis from putrescine and S-adenosylmethionine
GenProp0642putrescine biosynthesis from arginine utilizing agmatinase
GenProp0643putrescine biosynthesis from arginine via ornithine
GenProp0644putrescine biosynthesis from glutamate via ornithine
GenProp0645putrescine biosynthesis
GenProp0738agmatine to putrescine via N-carbamoylputrescine
GenProp0795carbohydrate biosynthesis
GenProp0838lipid biosynthesis
GenProp0909capreomycidine biosynthesis
GenProp0942alkane biosynthesis, cyanobacterial
GenProp1053rSAM/selenodomain system
GenProp1056rhizo-twelve system
GenProp1057radical SAM/SPASM system GeoRSP
GenProp0014polyketide biosynthesis, type I
GenProp0015polyketide biosynthesis, type II
GenProp0040thiotemplate type non-ribosomal peptide biosynthesis
GenProp0169hybrid NRPS-PKS natural pruduct biosynthesis genes
GenProp0757quorum-sensing, autoinducer-2 system
GenProp0758lycopene biosynthesis from IPP
GenProp0770siderophore biosynthesis
GenProp0807bacteriocin system, heterocycle biosynthesis group
GenProp0808bacteriocin system, TIGR01847 leader group
GenProp0809bacteriocin system, lactococcin 972 group
GenProp0810bacteriocin system, linocin M18 group
GenProp0823violacein biosynthesis
GenProp0825bacteriocin system, circular bacteriocin group
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0861bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group
GenProp0901post-ribosomal natural product synthesis system, Burkholderia TOMM-type
GenProp0919SCIFF/radical SAM Clostridial gene pair
GenProp0920radical SAM Y_X(10)_GDL system
GenProp0921radical SAM pair and His-Xaa-Ser repeats peptide
GenProp0936bacteriocin system, sporulation delay protein group
GenProp0945radical SAM maturase bacteriocin system, CLI_3235 type
GenProp0954radical SAM-cylized peptide, Pep1357C family
GenProp0955modified peptide/radical SAM maturase system, YydFG family
GenProp0956radical SAM maturase/selenobacteriocin system
GenProp0962methanobactin biosynthesis, Mb-OB3b family
GenProp0967radical SAM maturase system, CXXX repeats type
GenProp0982radical SAM maturase system, FibroRumin system
GenProp0984radical SAM maturase system, GG-Bacteroidales group
GenProp0990cobaltopeptin biosynthesis
GenProp0991ATP-grasp maturase system, microviridin/marinostatin class
GenProp1000ATP-grasp maturase system, uncharacterized
GenProp1002grasp-with-spasm peptide maturase system
GenProp1003cysteine S-glycopeptide biosynthesis, sublancin family
GenProp1029radical SAM/SPASM system SynChlorMet
GenProp1037radical SAM/SPASM system GRRM
GenProp1052geopeptide radical SAM/SPASM maturase system
GenProp1062radical SAM/SPASM system Clo7bot
GenProp1065radical SAM/SPASM TIGR04347/TIGR04031 system
GenProp1078sporulation killing factor system
GenProp1083cyanobactin-like ribosomal natural product biosynthesis
GenProp1084enduracididine biosynthesis
GenProp1090radical SAM/SPASM maturase system XYE
GenProp0190phosphate ABC transporter (pstSCAB-phoU)
GenProp0241phosphonate catabolism
GenProp0243ATP synthases