Genome Property Definition Page

AccessionGenProp0725
Nameouter membrane protein assembly complex
TypeMETAPATH
DescriptionCorrect assembly of proteins in the bacterial outer membrane is facilitated by a protein complex, consisting largely of lipoproteins, plus a member of the Omp85 protein family, named YaeT in Escherichia coli.
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0069: cell surface component
GenProp0069: cell surface component
GenProp0069: cell surface component
GenProp0248: protein folding
GenProp0248: protein folding
GenProp0248: protein folding
Literature References
[ 1 ]Malinverni JC, Werner J, Kim S, Sklar JG, Kahne D, Misra R, Silhavy TJ  YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli.  Mol Microbiol. 2006 Jul;61(1):151-64.  PMID 16824102
[ 2 ]Robert V, Volokhina EB, Senf F, Bos MP, Van Gelder P, Tommassen J  Assembly factor Omp85 recognizes its outer membrane protein substrates by a species-specific C-terminal motif.  PLoS Biol. 2006 Nov;4(11):e377.  PMID 17090219
[ 3 ] Charlson ES, Werner JN, Misra R   Differential effects of yfgL mutation on Escherichia coli outer membrane proteins and lipopolysaccharide.   J Bacteriol. 2006 Oct;188(20):7186-94.  PMID 17015657
[ 4 ]Hagan CL, Kim S, Kahne D  Reconstitution of outer membrane protein assembly from purified components.  Science. 2010 May 14;328(5980):890-2. Epub 2010 Apr 8.  PMID 20378773
[ 1 ]Malinverni JC, Werner J, Kim S, Sklar JG, Kahne D, Misra R, Silhavy TJ  YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli.  Mol Microbiol. 2006 Jul;61(1):151-64.  PMID 16824102
[ 2 ]Robert V, Volokhina EB, Senf F, Bos MP, Van Gelder P, Tommassen J  Assembly factor Omp85 recognizes its outer membrane protein substrates by a species-specific C-terminal motif.  PLoS Biol. 2006 Nov;4(11):e377.  PMID 17090219
[ 3 ] Charlson ES, Werner JN, Misra R   Differential effects of yfgL mutation on Escherichia coli outer membrane proteins and lipopolysaccharide.   J Bacteriol. 2006 Oct;188(20):7186-94.  PMID 17015657
[ 4 ]Hagan CL, Kim S, Kahne D  Reconstitution of outer membrane protein assembly from purified components.  Science. 2010 May 14;328(5980):890-2. Epub 2010 Apr 8.  PMID 20378773
[ 1 ]Malinverni JC, Werner J, Kim S, Sklar JG, Kahne D, Misra R, Silhavy TJ  YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli.  Mol Microbiol. 2006 Jul;61(1):151-64.  PMID 16824102
[ 2 ]Robert V, Volokhina EB, Senf F, Bos MP, Van Gelder P, Tommassen J  Assembly factor Omp85 recognizes its outer membrane protein substrates by a species-specific C-terminal motif.  PLoS Biol. 2006 Nov;4(11):e377.  PMID 17090219
[ 3 ] Charlson ES, Werner JN, Misra R   Differential effects of yfgL mutation on Escherichia coli outer membrane proteins and lipopolysaccharide.   J Bacteriol. 2006 Oct;188(20):7186-94.  PMID 17015657
[ 4 ]Hagan CL, Kim S, Kahne D  Reconstitution of outer membrane protein assembly from purified components.  Science. 2010 May 14;328(5980):890-2. Epub 2010 Apr 8.  PMID 20378773
Gene Ontology TermGO:0006886: intracellular protein transport (biological_process)
GO:0006886: intracellular protein transport (biological_process)
GO:0006886: intracellular protein transport (biological_process)
GO:0006458: 'de novo' protein folding (biological_process)
GO:0006458: 'de novo' protein folding (biological_process)
GO:0006458: 'de novo' protein folding (biological_process)
GO:0006886: intracellular protein transport (biological_process)
GO:0006886: intracellular protein transport (biological_process)
GO:0006886: intracellular protein transport (biological_process)
GO:0006458: 'de novo' protein folding (biological_process)
GO:0006458: 'de novo' protein folding (biological_process)
GO:0006458: 'de novo' protein folding (biological_process)
GO:0032978: protein insertion into membrane from inner side (biological_process)
GO:0032978: protein insertion into membrane from inner side (biological_process)
GO:0032978: protein insertion into membrane from inner side (biological_process)
GO:0032978: protein insertion into membrane from inner side (biological_process)
GO:0032978: protein insertion into membrane from inner side (biological_process)
GO:0032978: protein insertion into membrane from inner side (biological_process)
GO:0061077: chaperone-mediated protein folding (biological_process)
GO:0061077: chaperone-mediated protein folding (biological_process)
GO:0061077: chaperone-mediated protein folding (biological_process)
GO:0061077: chaperone-mediated protein folding (biological_process)
GO:0061077: chaperone-mediated protein folding (biological_process)
GO:0061077: chaperone-mediated protein folding (biological_process)
GO:0006886: intracellular protein transport (biological_process)
GO:0006886: intracellular protein transport (biological_process)
GO:0006886: intracellular protein transport (biological_process)
GO:0006458: 'de novo' protein folding (biological_process)
GO:0006458: 'de novo' protein folding (biological_process)
GO:0006458: 'de novo' protein folding (biological_process)
GO:0032978: protein insertion into membrane from inner side (biological_process)
GO:0032978: protein insertion into membrane from inner side (biological_process)
GO:0032978: protein insertion into membrane from inner side (biological_process)
GO:0061077: chaperone-mediated protein folding (biological_process)
GO:0061077: chaperone-mediated protein folding (biological_process)
GO:0061077: chaperone-mediated protein folding (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
OMP insertion complex protein BamA/YaeTBamAYESTIGR03303 (HMM): outer membrane protein assembly complex, YaeT proteinGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex protein BamA/YaeTBamAYESTIGR03303 (HMM): outer membrane protein assembly complex, YaeT proteinGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex protein BamA/YaeTBamAYESTIGR03303 (HMM): outer membrane protein assembly complex, YaeT proteinGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamB/YfgLBamBNOTIGR03300 (HMM): outer membrane assembly lipoprotein YfgLGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamB/YfgLBamBNOTIGR03300 (HMM): outer membrane assembly lipoprotein YfgLGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamB/YfgLBamBNOTIGR03300 (HMM): outer membrane assembly lipoprotein YfgLGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamC/NlpBBamCNOPF06804 (HMM): NlpB/DapX lipoproteinGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamC/NlpBBamCNOPF06804 (HMM): NlpB/DapX lipoproteinGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamC/NlpBBamCNOPF06804 (HMM): NlpB/DapX lipoproteinGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamD/YfiOBamDYESTIGR03302 (HMM): outer membrane assembly lipoprotein YfiOGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamD/YfiOBamDYESTIGR03302 (HMM): outer membrane assembly lipoprotein YfiOGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamD/YfiOBamDYESTIGR03302 (HMM): outer membrane assembly lipoprotein YfiOGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamE/SmpABamENOPF04355 (HMM): SmpA/OmlA familyGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamE/SmpABamENOPF04355 (HMM): SmpA/OmlA familyGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion complex lipoprotein BamE/SmpABamENOPF04355 (HMM): SmpA/OmlA familyGO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP insertion C-terminal signalOM_targNOTIGR03304 (HMM): outer membrane insertion C-terminal signal
OMP insertion C-terminal signalOM_targNOTIGR03304 (HMM): outer membrane insertion C-terminal signal
OMP insertion C-terminal signalOM_targNOTIGR03304 (HMM): outer membrane insertion C-terminal signal
OMP chaperone system: SurA-Skp-DegPchaperonYESGenProp0928 (GENPROP): OMP chaperone system: SurA-Skp-DegP
GO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP chaperone system: SurA-Skp-DegPchaperonYESGenProp0928 (GENPROP): OMP chaperone system: SurA-Skp-DegP
GO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side
OMP chaperone system: SurA-Skp-DegPchaperonYESGenProp0928 (GENPROP): OMP chaperone system: SurA-Skp-DegP
GO:0006886: intracellular protein transport
GO:0006458: 'de novo' protein folding
GO:0061077: chaperone-mediated protein folding
GO:0032978: protein insertion into membrane from inner side

Parent Properties
AccessionName
GenProp0069cell surface component
GenProp0069cell surface component
GenProp0069cell surface component
GenProp0248protein folding
GenProp0248protein folding
GenProp0248protein folding

Child Properties
AccessionName
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0928OMP chaperone system: SurA-Skp-DegP

Sibling Properties
AccessionName
GenProp0007flagella
GenProp0012outer membrane
GenProp0022S-layer
GenProp0056type IV pilus
GenProp0062capsule
GenProp0158peptidoglycan(murein) biosynthesis
GenProp0297lipopolysaccharide biosynthesis
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0811S-layer homology domain-mediated cell wall binding
GenProp0847exosporium
GenProp0857anchored repeat-class ABC transporter, P. acnes type
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0244chaperone system: DnaK-DnaJ-GrpE
GenProp0245chaperone system: GroEL/GroES
GenProp0246chaperone system: thermosome/prefoldin
GenProp0928OMP chaperone system: SurA-Skp-DegP