Accession | GenProp0735 |
Name | type VI secretion |
Type | SYSTEM |
Description | The protein secretion system now called type VI has been described by Pukatzki, et al., Mougous. et al. and others. Two components of the system resemble components of type IV secretion systems (T6SS). Many species that carry this system have known pathogenic activity, but T6SS may be directed against other bacteria rather then eukaryotic cells. In addition to protein families for this system identified in various publications, several were identified by the partial phylogenetic programming algorithm (Haft, et al., PMID:16930487), supported by proximity to other type VI secretion genes. |
JCVI Role | Protein and peptide secretion and trafficking |
Parent Property | GenProp0179: protein transport
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Literature References | [ 1 ]Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordonez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science. 2006 Jun 9;312(5779):1526-30. PMID 16763151 [ 2 ]Rao PS, Yamada Y, Tan YP, Leung KY Use of proteomics to identify novel virulence determinants that are required for Edwardsiella tarda pathogenesis. Mol Microbiol. 2004 Jul;53(2):573-86. PMID 15228535 [ 3 ]Pukatzki S, Ma AT, Sturtevant D, Krastins B, Sarracino D, Nelson WC, Heidelberg JF, Mekalanos JJ Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1528-33. Epub 2006 Jan 23. PMID 16432199 [ 4 ] Mougous JD, Gifford CA, Ramsdell TL, Mekalanos JJ Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa. Nat Cell Biol. 2007 Jul;9(7):797-803. PMID 17558395 [ 5 ]Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions. PLoS Pathog. 2010 Aug 26;6(8):e1001068. PMID 20865170 |
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Gene Ontology Term | GO:0033103: protein secretion by the type VI secretion system (biological_process)
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Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
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type VI secretion system DotU family protein | VI_DotU | YES | TIGR03349 (HMM): type IV/VI secretion system protein, DotU family | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion protein, VC_A0108 family | VI_EvpB | YES | TIGR03355 (HMM): type VI secretion protein, EvpB/VC_A0108 family | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion system FHA domain protein | VI_FHA | YES | TIGR03354 (HMM): type VI secretion system FHA domain protein | GO:0033103: protein secretion by the type VI secretion system
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IcmF3-like protein | VI_IcmF | YES | TIGR03348 (HMM): type VI secretion protein IcmF | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion system OmpA/MotB domain | VI_OmpA | NO | TIGR03350 (HMM): type VI secretion system peptidoglycan-associated domain | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion ATPase ClpV1 | VI_clp | YES | TIGR03345 (HMM): type VI secretion ATPase, ClpV1 family | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion target, Hcp family | VI_hcp | YES | TIGR03344 (HMM): type VI secretion system effector, Hcp1 family | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion lipoprotein, VC_A0113 family | VI_lipo | YES | TIGR03352 (HMM): type VI secretion lipoprotein, VC_A0113 family | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion system Vgr family protein | VI_vgr | YES | TIGR03361 (HMM): type VI secretion system Vgr family protein | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion protein, VC_A0111 family | VI_xx_1 | YES | TIGR03347 (HMM): type VI secretion protein, VC_A0111 family | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion protein, VC_A0114 family | VI_xx_2 | YES | TIGR03353 (HMM): type VI secretion protein, VC_A0114 family | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion protein, VC_A0107 family | VI_xx_4 | YES | TIGR03358 (HMM): type VI secretion protein, VC_A0107 family | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion protein, VC_A0110 family | VI_xx_5 | YES | TIGR03359 (HMM): type VI secretion protein, TIGR03359 family | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion system lysozyme-like protein | VI_zyme | YES | TIGR03357 (HMM): type VI secretion system lysozyme-like protein | GO:0033103: protein secretion by the type VI secretion system
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type VI secretion-associated protein, VC_A0118 family | minor_1 | NO | TIGR03360 (HMM): type VI secretion-associated protein, VC_A0118 family | |
type VI secretion-associated protein, VC_A0119 family | minor_2 | NO | TIGR03362 (HMM): type VI secretion-associated protein, VC_A0119 family | |
type VI secretion-associated protein, BMA_A0402 family | minor_3 | NO | TIGR03363 (HMM): type VI secretion-associated protein, ImpA family | |
type VI secretion-associated protein, BMA_A0400 | minor_4 | NO | TIGR03373 (HMM): type VI secretion-associated protein, BMA_A0400 family | |
Accession | Name |
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GenProp0052 | type III secretion |
GenProp0053 | type II secretion |
GenProp0054 | type IV secretion |
GenProp0059 | type I secretion |
GenProp0127 | Tat (Sec-independent) protein export |
GenProp0205 | signal recognition system, bacterial |
GenProp0207 | lipoprotein localization system lolABCDE |
GenProp0209 | Sec system preprotein translocase |
GenProp0295 | prokaryotic N-terminal cleavage/methylation, type IV pilin-like |
GenProp0326 | protein sorting system, PEP-CTERM/exosortase (generic) |
GenProp0626 | protein sorting system, sortase type, LPXTG/SrtA class |
GenProp0664 | protein sorting system, sortase type, SrtB class |
GenProp0669 | protein sorting system, putative, exosortase G class |
GenProp0778 | protein sorting system, GlyGly-CTERM/rhombosortase |
GenProp0844 | accessory Sec system for serine-rich glycoprotein transport |
GenProp0845 | protein sorting system, KxYKxGKxW class |
GenProp0847 | exosporium |
GenProp0859 | protein sorting system, proteobacterial dedicated sortase type |
GenProp0904 | type VII secretion, Actinobacteria form |
GenProp0905 | type VII secretion, Firmicutes form |
GenProp0928 | OMP chaperone system: SurA-Skp-DegP |
GenProp0957 | protein sorting system, SipW class |
GenProp0978 | protein sorting system, PGF-CTERM/archaeosortase A |
GenProp0979 | protein sorting system, PEF-CTERM/archaeosortase C |
GenProp0980 | protein sorting system, putative, exosortase F class |
GenProp0983 | protein sorting system, VPXXXP-CTERM/archaeosortase B |
GenProp0985 | protein sorting system, VPDSG-CTERM/exosortase C |
GenProp0986 | protein sorting system, VPLPA-CTERM/exosortase D |
GenProp0987 | protein sorting system, cyano-PEP-CTERM class |
GenProp0989 | protein sorting system, VPEID-CTERM/exosortase E |
GenProp0993 | protein sorting system, PIP-CTERM/archaeosortase D |
GenProp0996 | protein sorting system, IPTLxxWG-CTERM/exosortase H |
GenProp0999 | Por secretion system |
GenProp1005 | protein sorting system, putative, exosortase J class |
GenProp1054 | protein sorting system, MSEP-CTERM/exosortase K |
GenProp1055 | protein sorting system, PEFG-CTERM/thaumarchaeosortase |
GenProp1074 | type V secretion |
GenProp1087 | protein sorting system, vault protein/exosortase N |
GenProp1102 | protein sorting system, CGP-CTERM/unknown of Thermococcaceae |
GenProp1103 | protein sorting system, Synergist-CTERM/unknown of Synergistetes |