Genome Property Definition Page

AccessionGenProp0735
Nametype VI secretion
TypeSYSTEM
DescriptionThe protein secretion system now called type VI has been described by Pukatzki, et al., Mougous. et al. and others. Two components of the system resemble components of type IV secretion systems (T6SS). Many species that carry this system have known pathogenic activity, but T6SS may be directed against other bacteria rather then eukaryotic cells. In addition to protein families for this system identified in various publications, several were identified by the partial phylogenetic programming algorithm (Haft, et al., PMID:16930487), supported by proximity to other type VI secretion genes.
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0179: protein transport
Literature References
[ 1 ]Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordonez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ  A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.  Science. 2006 Jun 9;312(5779):1526-30.  PMID 16763151
[ 2 ]Rao PS, Yamada Y, Tan YP, Leung KY  Use of proteomics to identify novel virulence determinants that are required for Edwardsiella tarda pathogenesis.  Mol Microbiol. 2004 Jul;53(2):573-86.  PMID 15228535
[ 3 ]Pukatzki S, Ma AT, Sturtevant D, Krastins B, Sarracino D, Nelson WC, Heidelberg JF, Mekalanos JJ  Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system.  Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1528-33. Epub 2006 Jan 23.  PMID 16432199
[ 4 ] Mougous JD, Gifford CA, Ramsdell TL, Mekalanos JJ   Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa.   Nat Cell Biol. 2007 Jul;9(7):797-803.  PMID 17558395
[ 5 ]Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD  Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.  PLoS Pathog. 2010 Aug 26;6(8):e1001068.  PMID 20865170
Gene Ontology TermGO:0033103: protein secretion by the type VI secretion system (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
type VI secretion system DotU family proteinVI_DotUYESTIGR03349 (HMM): type IV/VI secretion system protein, DotU familyGO:0033103: protein secretion by the type VI secretion system
type VI secretion protein, VC_A0108 familyVI_EvpBYESTIGR03355 (HMM): type VI secretion protein, EvpB/VC_A0108 familyGO:0033103: protein secretion by the type VI secretion system
type VI secretion system FHA domain proteinVI_FHAYESTIGR03354 (HMM): type VI secretion system FHA domain proteinGO:0033103: protein secretion by the type VI secretion system
IcmF3-like proteinVI_IcmFYESTIGR03348 (HMM): type VI secretion protein IcmFGO:0033103: protein secretion by the type VI secretion system
type VI secretion system OmpA/MotB domainVI_OmpANOTIGR03350 (HMM): type VI secretion system peptidoglycan-associated domainGO:0033103: protein secretion by the type VI secretion system
type VI secretion ATPase ClpV1VI_clpYESTIGR03345 (HMM): type VI secretion ATPase, ClpV1 familyGO:0033103: protein secretion by the type VI secretion system
type VI secretion target, Hcp familyVI_hcpYESTIGR03344 (HMM): type VI secretion system effector, Hcp1 familyGO:0033103: protein secretion by the type VI secretion system
type VI secretion lipoprotein, VC_A0113 familyVI_lipoYESTIGR03352 (HMM): type VI secretion lipoprotein, VC_A0113 familyGO:0033103: protein secretion by the type VI secretion system
type VI secretion system Vgr family proteinVI_vgrYESTIGR03361 (HMM): type VI secretion system Vgr family proteinGO:0033103: protein secretion by the type VI secretion system
type VI secretion protein, VC_A0111 familyVI_xx_1YESTIGR03347 (HMM): type VI secretion protein, VC_A0111 familyGO:0033103: protein secretion by the type VI secretion system
type VI secretion protein, VC_A0114 familyVI_xx_2YESTIGR03353 (HMM): type VI secretion protein, VC_A0114 familyGO:0033103: protein secretion by the type VI secretion system
type VI secretion protein, VC_A0107 familyVI_xx_4YESTIGR03358 (HMM): type VI secretion protein, VC_A0107 familyGO:0033103: protein secretion by the type VI secretion system
type VI secretion protein, VC_A0110 familyVI_xx_5YESTIGR03359 (HMM): type VI secretion protein, TIGR03359 familyGO:0033103: protein secretion by the type VI secretion system
type VI secretion system lysozyme-like proteinVI_zymeYESTIGR03357 (HMM): type VI secretion system lysozyme-like proteinGO:0033103: protein secretion by the type VI secretion system
type VI secretion-associated protein, VC_A0118 familyminor_1NOTIGR03360 (HMM): type VI secretion-associated protein, VC_A0118 family
type VI secretion-associated protein, VC_A0119 familyminor_2NOTIGR03362 (HMM): type VI secretion-associated protein, VC_A0119 family
type VI secretion-associated protein, BMA_A0402 familyminor_3NOTIGR03363 (HMM): type VI secretion-associated protein, ImpA family
type VI secretion-associated protein, BMA_A0400minor_4NOTIGR03373 (HMM): type VI secretion-associated protein, BMA_A0400 family

Parent Properties
AccessionName
GenProp0179protein transport


Sibling Properties
AccessionName
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0847exosporium
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N