Genome Property Definition Page

Nameglyoxalase pathway, glutathione dependent
DescriptionGlyoxalase I and glyoxalase II are the enzymes lactoylglutathione lyase (EC and hydroxyacylglutathione hydrolase (EC, respectively. This system detoxifies methylglyoxal and other highly reactive aldehydes. Glutathione serves a cofactor; variants of this pathway may occur where glutathione is replaced by another cofactor such as trypanothione in Trypanosoma cruzi (see PMID:16958620).
JCVI RoleDetoxification
Parent PropertyGenProp0303: detoxification
Literature References
[ 1 ]O'Young J, Sukdeo N, Honek JF  Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme.  Arch Biochem Biophys. 2007 Mar 1;459(1):20-6. Epub 2006 Dec 6.  PMID 17196158
Gene Ontology TermGO:0051596: methylglyoxal catabolic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
lactoylglutathione lyase (glyoxalase I)glox_IYESTIGR00068 (HMM): lactoylglutathione lyaseGO:0051596: methylglyoxal catabolic process
hydroxyacylglutathione hydrolase (glyoxalase II)glox_IIYESTIGR03413 (HMM): hydroxyacylglutathione hydrolaseGO:0051596: methylglyoxal catabolic process

Parent Properties

Sibling Properties
GenProp0151resistance to mercury
GenProp0213Resistance to Reactive Oxygen Species (ROS)
GenProp0474arsenical resistance system
GenProp0488superoxide dismutase, nickel-type
GenProp0562formaldehyde detoxification, glutathione-dependent
GenProp0673ribulose monophosphate pathway
GenProp0676alkylhydroperoxide reductase AhpCF (peroxiredoxin)