Genome Property Definition Page

AccessionGenProp0753
Namemycothiol biosynthesis
TypePATHWAY
DescriptionMycothiol is a thiol, a glutathione analog, found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and related species. Four genes associated with its biosynthesis, designated mshA, mshB, mshC, and mshD, are scattered in the M. tuberculosis genome rather than arranged as an operon. A fifth reaction associated with this biosynthesis, a phosphatase designated MsaA2, has been described by, apparently, not yet assigned to a specific protein. Genomes with this biosynthesis system will have other proteins that make use of mycothiol.
JCVI RoleGlutathione and analogs
Parent PropertyGenProp0184: cofactor biosynthesis
Literature References
[ 1 ]Newton GL, Ta P, Sareen D, Fahey RC.  A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening.  Anal Biochem. 2006 Jun 15;353(2):167-73.  PMID 16674910
Gene Ontology TermGO:0010125: mycothiol biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
D-inositol-3-phosphate glycosyltransferaseMshAYESTIGR03449 (HMM): D-inositol-3-phosphate glycosyltransferaseGO:0010125: mycothiol biosynthetic process
mycothiol biosynthesis protein BMshBYESTIGR03445 (HMM): N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylaseGO:0010125: mycothiol biosynthetic process
mycothiol biosynthesis Cys ligaseMshCYESTIGR03447 (HMM): cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligaseGO:0010125: mycothiol biosynthetic process
mycothiol biosynthesis acetyltransferaseMshDYESTIGR03448 (HMM): mycothiol synthaseGO:0010125: mycothiol biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis