Genome Property Definition Page

AccessionGenProp0760
Nameputrescine degradation to GABA via gamma-glutamylation
TypePATHWAY
DescriptionFour sequential enzymatic steps catalyze the degradation of putrescine to GABA (gamma-aminobutyrate) in Escherichia coli and related species by way of gamma-glutamylated intermediates. This modification prevents occurrence of the unstable compound gamma-aminobutyraldhyde as an intermediate. Note that mammalian cells appear to achieve a similar protection for putrescine degradation by acetylation rather than gamma-glutamylation. Genes for regulation of the system (puuR, previously ycjC), for import of putrescine (puuP, previously ycjJ), and for the conversion of GABA to succination semialdehyde (goaG) and then succinate (gabD) are associated with this pathway but not modeled at present as part of this Genome Property.
JCVI RoleAmino acids and amines
Parent PropertyGenProp0142: catabolism
Literature References
[ 1 ] Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H   A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.   J Biol Chem. 2005 Feb 11;280(6):4602-8.  PMID 15590624

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
glutamate--putrescine ligasepuuAYES60 (RULE_BASE)
gamma-glutamylputrescine oxidasepuuBYES61 (RULE_BASE)
gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenasepuuCYES62 (RULE_BASE)
gamma-glutamyl-gamma-aminobutyrate hydrolasepuuDYES63 (RULE_BASE)

Parent Properties
AccessionName
GenProp0142catabolism


Sibling Properties
AccessionName
GenProp0055polyhydroxyalkanoic acids
GenProp0141galactose-6-phosphate degradation via tagatose-6-phosphate
GenProp0156cyanophycin-like storage polymers
GenProp0168glycogen system
GenProp0210phenylacetic acid catabolism
GenProp02314-hydroxyphenylacetate degradation
GenProp0233GABA utilization
GenProp02382-aminoethylphosphonate catabolism to acetaldehyde
GenProp0239propionyl-CoA catabolism
GenProp0241phosphonate catabolism
GenProp0271trehalose utilization
GenProp0272pyruvate fermentation to acetoin
GenProp0273protocatechuate degradation to beta-ketoadipate
GenProp0283beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA
GenProp0294ethanolamine catabolism to acetaldehyde
GenProp0457rhamnose catabolism
GenProp0458fucose catabolism
GenProp0461utilization of deoxynucleosides
GenProp0653ectoine catabolism
GenProp0674malonate decarboxylase
GenProp0686allantoin catabolism to glyoxalate and urea
GenProp0687allantoin catabolism to oxamate and carbamoyl-phosphate
GenProp0688urate catabolism to allantoin
GenProp0691glycolysis
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp0700purine catabolism via urate, xanthine and allantoin
GenProp0702benzoyl-CoA reductase
GenProp07034-hydroxybenzoyl-CoA reductase
GenProp0706cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway
GenProp0708catechol meta-cleavage pathway
GenProp0709benzoate catabolism BoxABC pathway
GenProp0711catechol ortho-cleavage upper pathway
GenProp0714galactarate utilization via tartronate semi-aldehyde
GenProp0715galactarate utilization via 2-oxoglutarate semialdehyde
GenProp0716glucarate utilization via tartronate semi-aldehyde
GenProp0717glucarate utilization via 2-oxoglutarate semialdehyde
GenProp0718oxalate degradation
GenProp0734amino acid catabolism
GenProp0749choline sulfate utilization
GenProp0763nicotinate fermentation to pyruvate and propionate
GenProp0813pyrimidine utilization operon, RutABCDEFGR
GenProp0902quinohemoprotein amine dehydrogenase
GenProp1071myo-inositol catabolism
GenProp1072cyanase system
GenProp1076choline TMA-lyase system