Genome Property Definition Page

AccessionGenProp0761
Namehopanoid lipid biosynthesis
TypePATHWAY
DescriptionHopanoids are pentacyclic steroid-like compounds derived from squalene (a diterpene) by cyclization and various elaborations of the side chain. Methylations of the polycyclic body of the molecule have also been reported. The essential enzymes are squalene synthase which condenses two molecules of farnesyl-pyrophosphate and squalene-hopene cyclase.
Parent PropertyGenProp0838: lipid biosynthesis
GenProp0838: lipid biosynthesis
GenProp0838: lipid biosynthesis
Literature References
[ 1 ]Perzl M, Reipen IG, Schmitz S, Poralla K, Sahm H, Sprenger GA, Kannenberg EL  Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids.  Biochim Biophys Acta. 1998 Jul 31;1393(1):108-18.  PMID 9714766
[ 1 ]Perzl M, Reipen IG, Schmitz S, Poralla K, Sahm H, Sprenger GA, Kannenberg EL  Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids.  Biochim Biophys Acta. 1998 Jul 31;1393(1):108-18.  PMID 9714766
[ 1 ]Perzl M, Reipen IG, Schmitz S, Poralla K, Sahm H, Sprenger GA, Kannenberg EL  Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids.  Biochim Biophys Acta. 1998 Jul 31;1393(1):108-18.  PMID 9714766
Gene Ontology TermGO:0019746: hopanoid biosynthetic process (biological_process)
GO:0019746: hopanoid biosynthetic process (biological_process)
GO:0019746: hopanoid biosynthetic process (biological_process)
GO:0019746: hopanoid biosynthetic process (biological_process)
GO:0019746: hopanoid biosynthetic process (biological_process)
GO:0019746: hopanoid biosynthetic process (biological_process)
GO:0019746: hopanoid biosynthetic process (biological_process)
GO:0019746: hopanoid biosynthetic process (biological_process)
GO:0019746: hopanoid biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
nucleotide-sugar epimerase/dehydrataseHpnANOTIGR03466 (HMM): hopanoid-associated sugar epimerase
TIGR03466 (HMM): hopanoid-associated sugar epimerase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
nucleotide-sugar epimerase/dehydrataseHpnANOTIGR03466 (HMM): hopanoid-associated sugar epimerase
TIGR03466 (HMM): hopanoid-associated sugar epimerase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
nucleotide-sugar epimerase/dehydrataseHpnANOTIGR03466 (HMM): hopanoid-associated sugar epimerase
TIGR03466 (HMM): hopanoid-associated sugar epimerase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
glycosyl transferase, family 2, HpnBHpnBNOTIGR03469 (HMM): hopene-associated glycosyltransferase HpnB
TIGR03469 (HMM): hopene-associated glycosyltransferase HpnB
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
glycosyl transferase, family 2, HpnBHpnBNOTIGR03469 (HMM): hopene-associated glycosyltransferase HpnB
TIGR03469 (HMM): hopene-associated glycosyltransferase HpnB
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
glycosyl transferase, family 2, HpnBHpnBNOTIGR03469 (HMM): hopene-associated glycosyltransferase HpnB
TIGR03469 (HMM): hopene-associated glycosyltransferase HpnB
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
squalene synthase, HpnC and/or HpnD subunitsHpnCDYESTIGR03464 (HMM): squalene synthase HpnC
TIGR03465 (HMM): squalene synthase HpnD
TIGR03464 (HMM): squalene synthase HpnC
TIGR03465 (HMM): squalene synthase HpnD
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
squalene synthase, HpnC and/or HpnD subunitsHpnCDYESTIGR03464 (HMM): squalene synthase HpnC
TIGR03465 (HMM): squalene synthase HpnD
TIGR03464 (HMM): squalene synthase HpnC
TIGR03465 (HMM): squalene synthase HpnD
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
squalene synthase, HpnC and/or HpnD subunitsHpnCDYESTIGR03464 (HMM): squalene synthase HpnC
TIGR03465 (HMM): squalene synthase HpnD
TIGR03464 (HMM): squalene synthase HpnC
TIGR03465 (HMM): squalene synthase HpnD
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
FAD-dependent desaturase, HpnEHpnENOTIGR03467 (HMM): squalene-associated FAD-dependent desaturase
TIGR03467 (HMM): squalene-associated FAD-dependent desaturase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
FAD-dependent desaturase, HpnEHpnENOTIGR03467 (HMM): squalene-associated FAD-dependent desaturase
TIGR03467 (HMM): squalene-associated FAD-dependent desaturase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
FAD-dependent desaturase, HpnEHpnENOTIGR03467 (HMM): squalene-associated FAD-dependent desaturase
TIGR03467 (HMM): squalene-associated FAD-dependent desaturase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
phosphorylase, HpnGHpnGNOTIGR03468 (HMM): hopanoid-associated phosphorylase
TIGR03468 (HMM): hopanoid-associated phosphorylase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
phosphorylase, HpnGHpnGNOTIGR03468 (HMM): hopanoid-associated phosphorylase
TIGR03468 (HMM): hopanoid-associated phosphorylase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
phosphorylase, HpnGHpnGNOTIGR03468 (HMM): hopanoid-associated phosphorylase
TIGR03468 (HMM): hopanoid-associated phosphorylase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
radical SAM enzyme, HpnHHpnHYESTIGR03470 (HMM): hopanoid biosynthesis associated radical SAM protein HpnH
TIGR03470 (HMM): hopanoid biosynthesis associated radical SAM protein HpnH
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
radical SAM enzyme, HpnHHpnHYESTIGR03470 (HMM): hopanoid biosynthesis associated radical SAM protein HpnH
TIGR03470 (HMM): hopanoid biosynthesis associated radical SAM protein HpnH
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
radical SAM enzyme, HpnHHpnHYESTIGR03470 (HMM): hopanoid biosynthesis associated radical SAM protein HpnH
TIGR03470 (HMM): hopanoid biosynthesis associated radical SAM protein HpnH
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
glycosyl transferase, family 2, HpnIHpnINOTIGR03472 (HMM): hopanoid biosynthesis associated glycosyl transferase protein HpnI
TIGR03472 (HMM): hopanoid biosynthesis associated glycosyl transferase protein HpnI
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
glycosyl transferase, family 2, HpnIHpnINOTIGR03472 (HMM): hopanoid biosynthesis associated glycosyl transferase protein HpnI
TIGR03472 (HMM): hopanoid biosynthesis associated glycosyl transferase protein HpnI
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
glycosyl transferase, family 2, HpnIHpnINOTIGR03472 (HMM): hopanoid biosynthesis associated glycosyl transferase protein HpnI
TIGR03472 (HMM): hopanoid biosynthesis associated glycosyl transferase protein HpnI
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
radical SAM enzyme, HpnJHpnJNOTIGR03471 (HMM): hopanoid biosynthesis associated radical SAM protein HpnJ
TIGR03471 (HMM): hopanoid biosynthesis associated radical SAM protein HpnJ
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
radical SAM enzyme, HpnJHpnJNOTIGR03471 (HMM): hopanoid biosynthesis associated radical SAM protein HpnJ
TIGR03471 (HMM): hopanoid biosynthesis associated radical SAM protein HpnJ
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
radical SAM enzyme, HpnJHpnJNOTIGR03471 (HMM): hopanoid biosynthesis associated radical SAM protein HpnJ
TIGR03471 (HMM): hopanoid biosynthesis associated radical SAM protein HpnJ
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
YdjC-like enzyme, HpnKHpnKNOTIGR03473 (HMM): hopanoid biosynthesis associated protein HpnK
TIGR03473 (HMM): hopanoid biosynthesis associated protein HpnK
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
YdjC-like enzyme, HpnKHpnKNOTIGR03473 (HMM): hopanoid biosynthesis associated protein HpnK
TIGR03473 (HMM): hopanoid biosynthesis associated protein HpnK
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
YdjC-like enzyme, HpnKHpnKNOTIGR03473 (HMM): hopanoid biosynthesis associated protein HpnK
TIGR03473 (HMM): hopanoid biosynthesis associated protein HpnK
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
putative membrane protein, TIGR00374 superfamily, HpnLHpnLNOTIGR03476 (HMM): putative membrane protein
TIGR03476 (HMM): putative membrane protein
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
putative membrane protein, TIGR00374 superfamily, HpnLHpnLNOTIGR03476 (HMM): putative membrane protein
TIGR03476 (HMM): putative membrane protein
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
putative membrane protein, TIGR00374 superfamily, HpnLHpnLNOTIGR03476 (HMM): putative membrane protein
TIGR03476 (HMM): putative membrane protein
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
toluene tolerance protein homolog, HpnMHpnMNOTIGR03481 (HMM): hopanoid biosynthesis associated membrane protein HpnM
TIGR03481 (HMM): hopanoid biosynthesis associated membrane protein HpnM
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
toluene tolerance protein homolog, HpnMHpnMNOTIGR03481 (HMM): hopanoid biosynthesis associated membrane protein HpnM
TIGR03481 (HMM): hopanoid biosynthesis associated membrane protein HpnM
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
toluene tolerance protein homolog, HpnMHpnMNOTIGR03481 (HMM): hopanoid biosynthesis associated membrane protein HpnM
TIGR03481 (HMM): hopanoid biosynthesis associated membrane protein HpnM
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
RND efflux transporter homolog, HpnNHpnNNOTIGR03480 (HMM): hopanoid biosynthesis associated RND transporter like protein HpnN
TIGR03480 (HMM): hopanoid biosynthesis associated RND transporter like protein HpnN
RND efflux transporter homolog, HpnNHpnNNOTIGR03480 (HMM): hopanoid biosynthesis associated RND transporter like protein HpnN
TIGR03480 (HMM): hopanoid biosynthesis associated RND transporter like protein HpnN
RND efflux transporter homolog, HpnNHpnNNOTIGR03480 (HMM): hopanoid biosynthesis associated RND transporter like protein HpnN
TIGR03480 (HMM): hopanoid biosynthesis associated RND transporter like protein HpnN
VacJ like lipoproteinHpnONOPF04333 (HMM-CLUST): lipid assymetry maintenance protein MlaA
PF04333 (HMM-CLUST): lipid assymetry maintenance protein MlaA
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
VacJ like lipoproteinHpnONOPF04333 (HMM-CLUST): lipid assymetry maintenance protein MlaA
PF04333 (HMM-CLUST): lipid assymetry maintenance protein MlaA
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
VacJ like lipoproteinHpnONOPF04333 (HMM-CLUST): lipid assymetry maintenance protein MlaA
PF04333 (HMM-CLUST): lipid assymetry maintenance protein MlaA
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
hopanoid C-3 methylaseHpnRNOTIGR04367 (HMM): hopanoid C-3 methylase HpnR
TIGR04367 (HMM): hopanoid C-3 methylase HpnR
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
hopanoid C-3 methylaseHpnRNOTIGR04367 (HMM): hopanoid C-3 methylase HpnR
TIGR04367 (HMM): hopanoid C-3 methylase HpnR
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
hopanoid C-3 methylaseHpnRNOTIGR04367 (HMM): hopanoid C-3 methylase HpnR
TIGR04367 (HMM): hopanoid C-3 methylase HpnR
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
squalene-hopene cyclaseSHCYESTIGR01507 (HMM): squalene-hopene cyclase
TIGR01507 (HMM): squalene-hopene cyclase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
squalene-hopene cyclaseSHCYESTIGR01507 (HMM): squalene-hopene cyclase
TIGR01507 (HMM): squalene-hopene cyclase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
squalene-hopene cyclaseSHCYESTIGR01507 (HMM): squalene-hopene cyclase
TIGR01507 (HMM): squalene-hopene cyclase
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process

Parent Properties
AccessionName
GenProp0838lipid biosynthesis
GenProp0838lipid biosynthesis
GenProp0838lipid biosynthesis


Sibling Properties
AccessionName
GenProp0046IPP biosynthesis
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0297lipopolysaccharide biosynthesis
GenProp0299fatty acid biosynthesis
GenProp0758lycopene biosynthesis from IPP
GenProp0836menaquinone biosynthesis
GenProp08371-acylglycerol-3-phosphate biosynthesis, PlsX/Y pathway