Genome Property Definition Page

Namehopanoid lipid biosynthesis
DescriptionHopanoids are pentacyclic steroid-like compounds derived from squalene (a diterpene) by cyclization and various elaborations of the side chain. Methylations of the polycyclic body of the molecule have also been reported. The essential enzymes are squalene synthase which condenses two molecules of farnesyl-pyrophosphate and squalene-hopene cyclase.
Parent PropertyGenProp0838: lipid biosynthesis
Literature References
[ 1 ]Perzl M, Reipen IG, Schmitz S, Poralla K, Sahm H, Sprenger GA, Kannenberg EL  Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids.  Biochim Biophys Acta. 1998 Jul 31;1393(1):108-18.  PMID 9714766
Gene Ontology TermGO:0019746: hopanoid biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
nucleotide-sugar epimerase/dehydrataseHpnANOTIGR03466 (HMM): hopanoid-associated sugar epimeraseGO:0019746: hopanoid biosynthetic process
glycosyl transferase, family 2, HpnBHpnBNOTIGR03469 (HMM): hopene-associated glycosyltransferase HpnBGO:0019746: hopanoid biosynthetic process
squalene synthase, HpnC and/or HpnD subunitsHpnCDYESTIGR03464 (HMM): squalene synthase HpnC
TIGR03465 (HMM): squalene synthase HpnD
GO:0019746: hopanoid biosynthetic process
GO:0019746: hopanoid biosynthetic process
FAD-dependent desaturase, HpnEHpnENOTIGR03467 (HMM): squalene-associated FAD-dependent desaturaseGO:0019746: hopanoid biosynthetic process
phosphorylase, HpnGHpnGNOTIGR03468 (HMM): hopanoid-associated phosphorylaseGO:0019746: hopanoid biosynthetic process
radical SAM enzyme, HpnHHpnHYESTIGR03470 (HMM): hopanoid biosynthesis associated radical SAM protein HpnHGO:0019746: hopanoid biosynthetic process
glycosyl transferase, family 2, HpnIHpnINOTIGR03472 (HMM): hopanoid biosynthesis associated glycosyl transferase protein HpnIGO:0019746: hopanoid biosynthetic process
radical SAM enzyme, HpnJHpnJNOTIGR03471 (HMM): hopanoid biosynthesis associated radical SAM protein HpnJGO:0019746: hopanoid biosynthetic process
YdjC-like enzyme, HpnKHpnKNOTIGR03473 (HMM): hopanoid biosynthesis associated protein HpnKGO:0019746: hopanoid biosynthetic process
putative membrane protein, TIGR00374 superfamily, HpnLHpnLNOTIGR03476 (HMM): putative membrane proteinGO:0019746: hopanoid biosynthetic process
toluene tolerance protein homolog, HpnMHpnMNOTIGR03481 (HMM): hopanoid biosynthesis associated membrane protein HpnMGO:0019746: hopanoid biosynthetic process
RND efflux transporter homolog, HpnNHpnNNOTIGR03480 (HMM): hopanoid biosynthesis associated RND transporter like protein HpnN
VacJ like lipoproteinHpnONOPF04333 (HMM-CLUST): lipid assymetry maintenance protein MlaAGO:0019746: hopanoid biosynthetic process
hopanoid C-3 methylaseHpnRNOTIGR04367 (HMM): hopanoid C-3 methylase HpnRGO:0019746: hopanoid biosynthetic process
squalene-hopene cyclaseSHCYESTIGR01507 (HMM): squalene-hopene cyclaseGO:0019746: hopanoid biosynthetic process

Parent Properties
GenProp0838lipid biosynthesis

Sibling Properties
GenProp0046IPP biosynthesis
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0297lipopolysaccharide biosynthesis
GenProp0299fatty acid biosynthesis
GenProp0758lycopene biosynthesis from IPP
GenProp0836menaquinone biosynthesis
GenProp08371-acylglycerol-3-phosphate biosynthesis, PlsX/Y pathway