Genome Property Definition Page

AccessionGenProp0763
Namenicotinate fermentation to pyruvate and propionate
TypePATHWAY
DescriptionThis property represents one of a number of distinct catabolic pathways for nicotinate (niacin, vitamin B3), a nine-enzyme anaerobic fermentation to pyruvate and propionate as in the anaerobic soil bacterium Eubacterium barkeri. The nicotinate dehydrogenase in E. barkeri is a four-subunit enzyme with a non-selenocysteine selenium that belongs to a family of selenium-dependent molybdenum hydroxylases.
JCVI RoleOther
Parent PropertyGenProp0142: catabolism
GenProp0298: fermentation
Literature References
[ 1 ] Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ   Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.   Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12341-6.  PMID 16894175
Gene Ontology TermGO:0046497: nicotinate nucleotide metabolic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
nicotinate dehydrogenase, FAD subunitn1_ndhFYES2080 (RULE_BASE)
GO:0046497: nicotinate nucleotide metabolic process
nicotinate dehydrogenase, NdhL subunitn1_ndhLYES
nicotinate dehydrogenase, NdhM subunitn1_ndhMYES
nicotinate dehydrogenase, 2x[2Fe-2S] subunitn1_ndhSYES2081 (RULE_BASE)
GO:0046497: nicotinate nucleotide metabolic process
6-hydroxynicotinate reductase (1.3.7.1)nic_2YES
enamidase (3.5.2.18)nic_3YES2082 (RULE_BASE)
GO:0046497: nicotinate nucleotide metabolic process
2-hydroxymethylglutarate dehydrogenase (1.1.1.291)nic_4YES
2-hydroxymethylglutarate dehydratasenic_5YES
2-methyleneglutarate mutase (5.4.99.4)nic_6YES2079 (RULE_BASE)
GO:0046497: nicotinate nucleotide metabolic process
methylitaconate Delta-isomerase (5.3.3.6)nic_7YES
dimethylmaleate hydratase (4.2.1.85)nic_8YES
2,3-dimethylmalate lyase (4.1.3.32)nic_9YES

Parent Properties
AccessionName
GenProp0142catabolism
GenProp0298fermentation


Sibling Properties
AccessionName
GenProp0055polyhydroxyalkanoic acids
GenProp0141galactose-6-phosphate degradation via tagatose-6-phosphate
GenProp0156cyanophycin-like storage polymers
GenProp0168glycogen system
GenProp0210phenylacetic acid catabolism
GenProp02314-hydroxyphenylacetate degradation
GenProp0233GABA utilization
GenProp02382-aminoethylphosphonate catabolism to acetaldehyde
GenProp0239propionyl-CoA catabolism
GenProp0241phosphonate catabolism
GenProp0271trehalose utilization
GenProp0272pyruvate fermentation to acetoin
GenProp0273protocatechuate degradation to beta-ketoadipate
GenProp0283beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA
GenProp0294ethanolamine catabolism to acetaldehyde
GenProp0457rhamnose catabolism
GenProp0458fucose catabolism
GenProp0461utilization of deoxynucleosides
GenProp0653ectoine catabolism
GenProp0674malonate decarboxylase
GenProp0686allantoin catabolism to glyoxalate and urea
GenProp0687allantoin catabolism to oxamate and carbamoyl-phosphate
GenProp0688urate catabolism to allantoin
GenProp0691glycolysis
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp0700purine catabolism via urate, xanthine and allantoin
GenProp0702benzoyl-CoA reductase
GenProp07034-hydroxybenzoyl-CoA reductase
GenProp0706cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway
GenProp0708catechol meta-cleavage pathway
GenProp0709benzoate catabolism BoxABC pathway
GenProp0711catechol ortho-cleavage upper pathway
GenProp0714galactarate utilization via tartronate semi-aldehyde
GenProp0715galactarate utilization via 2-oxoglutarate semialdehyde
GenProp0716glucarate utilization via tartronate semi-aldehyde
GenProp0717glucarate utilization via 2-oxoglutarate semialdehyde
GenProp0718oxalate degradation
GenProp0734amino acid catabolism
GenProp0749choline sulfate utilization
GenProp0760putrescine degradation to GABA via gamma-glutamylation
GenProp0813pyrimidine utilization operon, RutABCDEFGR
GenProp0902quinohemoprotein amine dehydrogenase
GenProp1071myo-inositol catabolism
GenProp1072cyanase system
GenProp1076choline TMA-lyase system
GenProp0765glycerol fermentation to 1,3-propanediol, using glycerol dehydratase