Genome Property Definition Page

Nameanhydro-N-acetylmuramic acid to N-acetylglucosamine-phosphate
DescriptionComponents of the bacterial murein cell wall, including 1,6-anhydro-N-acetylmuramic acid (anhMurNAc), N-acetyl-D-glucosamine (GlcNAc), D-alanine, and murein tripeptide are released during in murein recycling as bacteria grow. Pathways exist to recycle these components for the biosynthesis of new cell wall. This pathway describes a two-enzyme pathway for converting anhMurNAc into N-acetylglucosamine-phosphate.
JCVI RoleBiosynthesis and degradation of murein sacculus and peptidoglycan
Parent PropertyGenProp0795: carbohydrate biosynthesis
Literature References
[ 1 ] Uehara T, Suefuji K, Valbuena N, Meehan B, Donegan M, Park JT   Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate.   J Bacteriol. 2005 Jun;187(11):3643-9.  PMID 15901686
[ 2 ] Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT   MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.   J Bacteriol. 2006 Feb;188(4):1660-2.  PMID 16452451
Gene Ontology TermGO:0009254: peptidoglycan turnover (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
anhydro-N-acetylmuramic acid kinaseanmKYESPF03702 (HMM): anhydro-N-acetylmuramic acid kinaseGO:0009254: peptidoglycan turnover
N-acetylmuramic acid-phosphate etherasemurQYESTIGR00274 (HMM): N-acetylmuramic acid 6-phosphate etheraseGO:0009254: peptidoglycan turnover

Parent Properties
GenProp0795carbohydrate biosynthesis

Sibling Properties
GenProp0183dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose
GenProp0264glucosylglycerol biosynthesis
GenProp0297lipopolysaccharide biosynthesis
GenProp0750UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GenProp0793CMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine
GenProp0794proposed N-acetyl sugar amidation module WbuXYZ
GenProp0796CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine
GenProp0811S-layer homology domain-mediated cell wall binding