Accession | GenProp0774 |
Name | ferric citrate transport system |
Type | SYSTEM |
Description | Siderophores are chelators for ferric iron, that is, iron(III). Specific uptake systems for siderophores and their strong avidity for ferric iron compensate for the low availability of iron in certain environments. While some siderophores are derived from citrate, citrate itself chelates iron. Escherichia coli K-12, and some related enterobacteria, have a dedicated transport system for chelated iron in the form diferric dicitrate. This system exploits locally available citrate and obviates the need for siderophore biosynthesis and export. FecA is both a ferric citrate outer membrane transporter and signaling molecule that regulates transcription of the ferric citrate update system. FecBCDE is an ABC transporter complex. It appears that the iron ion is transported without the chelating citrate. FecR and FecI are regulatory proteins. |
JCVI Role | Cations and iron carrying compounds |
Parent Property | GenProp0820: iron metabolism
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Literature References | [ 1 ] Mahren S, Schnell H, Braun V Occurrence and regulation of the ferric citrate transport system in Escherichia coli B, Klebsiella pneumoniae, Enterobacter aerogenes, and Photorhabdus luminescens. Arch Microbiol. 2005 Nov;184(3):175-86. PMID 16193283 |
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Gene Ontology Term | GO:0015682: ferric iron transport (biological_process)
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Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
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TonB-dependent ferric citrate receptor FecA | FecA | YES | 2172 (RULE_BASE)
| GO:0015682: ferric iron transport
|
citrate-dependent iron(III) ABC transporter, periplasmic binding protein FecB | FecB | YES | 2173 (RULE_BASE)
| GO:0015682: ferric iron transport
|
citrate-dependent iron(III) ABC transporter, permease protein FecC | FecC | YES | 2174 (RULE_BASE)
| GO:0015682: ferric iron transport
|
citrate-dependent iron(III) ABC transporter, permease protein FecD | FecD | YES | 2175 (RULE_BASE)
| GO:0015682: ferric iron transport
|
citrate-dependent iron(III) ABC transporter, ATP-binding protein FecE | FecE | YES | 2176 (RULE_BASE)
| GO:0015682: ferric iron transport
|