Genome Property Definition Page

AccessionGenProp0774
Nameferric citrate transport system
TypeSYSTEM
DescriptionSiderophores are chelators for ferric iron, that is, iron(III). Specific uptake systems for siderophores and their strong avidity for ferric iron compensate for the low availability of iron in certain environments. While some siderophores are derived from citrate, citrate itself chelates iron. Escherichia coli K-12, and some related enterobacteria, have a dedicated transport system for chelated iron in the form diferric dicitrate. This system exploits locally available citrate and obviates the need for siderophore biosynthesis and export. FecA is both a ferric citrate outer membrane transporter and signaling molecule that regulates transcription of the ferric citrate update system. FecBCDE is an ABC transporter complex. It appears that the iron ion is transported without the chelating citrate. FecR and FecI are regulatory proteins.
JCVI RoleCations and iron carrying compounds
Parent PropertyGenProp0820: iron metabolism
GenProp0820: iron metabolism
GenProp0820: iron metabolism
Literature References
[ 1 ] Mahren S, Schnell H, Braun V   Occurrence and regulation of the ferric citrate transport system in Escherichia coli B, Klebsiella pneumoniae, Enterobacter aerogenes, and Photorhabdus luminescens.   Arch Microbiol. 2005 Nov;184(3):175-86.  PMID 16193283
[ 1 ] Mahren S, Schnell H, Braun V   Occurrence and regulation of the ferric citrate transport system in Escherichia coli B, Klebsiella pneumoniae, Enterobacter aerogenes, and Photorhabdus luminescens.   Arch Microbiol. 2005 Nov;184(3):175-86.  PMID 16193283
[ 1 ] Mahren S, Schnell H, Braun V   Occurrence and regulation of the ferric citrate transport system in Escherichia coli B, Klebsiella pneumoniae, Enterobacter aerogenes, and Photorhabdus luminescens.   Arch Microbiol. 2005 Nov;184(3):175-86.  PMID 16193283
Gene Ontology TermGO:0015682: ferric iron transport (biological_process)
GO:0015682: ferric iron transport (biological_process)
GO:0015682: ferric iron transport (biological_process)
GO:0015682: ferric iron transport (biological_process)
GO:0015682: ferric iron transport (biological_process)
GO:0015682: ferric iron transport (biological_process)
GO:0015682: ferric iron transport (biological_process)
GO:0015682: ferric iron transport (biological_process)
GO:0015682: ferric iron transport (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
TonB-dependent ferric citrate receptor FecAFecAYES2172 (RULE_BASE)
GO:0015682: ferric iron transport
TonB-dependent ferric citrate receptor FecAFecAYES2172 (RULE_BASE)
GO:0015682: ferric iron transport
TonB-dependent ferric citrate receptor FecAFecAYES2172 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, periplasmic binding protein FecBFecBYES2173 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, periplasmic binding protein FecBFecBYES2173 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, periplasmic binding protein FecBFecBYES2173 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, permease protein FecCFecCYES2174 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, permease protein FecCFecCYES2174 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, permease protein FecCFecCYES2174 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, permease protein FecDFecDYES2175 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, permease protein FecDFecDYES2175 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, permease protein FecDFecDYES2175 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, ATP-binding protein FecEFecEYES2176 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, ATP-binding protein FecEFecEYES2176 (RULE_BASE)
GO:0015682: ferric iron transport
citrate-dependent iron(III) ABC transporter, ATP-binding protein FecEFecEYES2176 (RULE_BASE)
GO:0015682: ferric iron transport

Parent Properties
AccessionName
GenProp0820iron metabolism
GenProp0820iron metabolism
GenProp0820iron metabolism


Sibling Properties
AccessionName
GenProp0140iron-sulfur cluster assembly systems
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0222protoheme from protoporphyrin IX
GenProp0627gene pair involved in iron and oxygen metabolism
GenProp0770siderophore biosynthesis
GenProp0828heme uptake system, NEAT-domain mediated
GenProp0961heme metabolism pair HutWX