Genome Property Definition Page

AccessionGenProp0777
Namestaphylobactin biosynthesis
TypeSYSTEM
DescriptionA nine-gene operon, sbn, encodes genes for staphylobactin biosynthesis and export. This siderophore, or ferric iron (Fe3+) chelator, contributes to survival, and therefore virulence, by Staphylococcus aureus in host tissues. Its reported size by m/z is 822, larger than staphyloferrins A (480) or B (448). SbnD appears to be the efflux transporter, SbnI is not homologous to known enzymes, and the other seven all appear by homology to be enzymes. Mutation of SbnE leads to a defect in staphylobactin biosynthesis, and an adjacent ABC transporter system, not currently part of this genome property, takes up ferric staphylobactin. Note that staphylobactin may be closely to staphyloferrin B, as all proteins but sbnI have close homologs in Ralstonia solanacearum GMI1000, which is phylogenetically extremely distant. R. solanacearum, however, makes staphyloferrin B like most strains of Staphylococcus aureus. S. aureus RN6390, meanwhile, appears to makes staphylobactin in place of staphyloferrin B.
JCVI RoleSiderophores
Parent PropertyGenProp0770: siderophore biosynthesis
GenProp0770: siderophore biosynthesis
Literature References
[ 1 ] Dale SE, Doherty-Kirby A, Lajoie G, Heinrichs DE   Role of siderophore biosynthesis in virulence of Staphylococcus aureus: identification and characterization of genes involved in production of a siderophore.   Infect Immun. 2004 Jan;72(1):29-37.  PMID 14688077
[ 2 ] Dale SE, Sebulsky MT, Heinrichs DE   Involvement of SirABC in iron-siderophore import in Staphylococcus aureus.   J Bacteriol. 2004 Dec;186(24):8356-62.  PMID 15576785
[ 3 ] Bhatt G, Denny TP   Ralstonia solanacearum iron scavenging by the siderophore staphyloferrin B is controlled by PhcA, the global virulence regulator.   J Bacteriol. 2004 Dec;186(23):7896-904.  PMID 15547261
[ 1 ] Dale SE, Doherty-Kirby A, Lajoie G, Heinrichs DE   Role of siderophore biosynthesis in virulence of Staphylococcus aureus: identification and characterization of genes involved in production of a siderophore.   Infect Immun. 2004 Jan;72(1):29-37.  PMID 14688077
[ 2 ] Dale SE, Sebulsky MT, Heinrichs DE   Involvement of SirABC in iron-siderophore import in Staphylococcus aureus.   J Bacteriol. 2004 Dec;186(24):8356-62.  PMID 15576785
[ 3 ] Bhatt G, Denny TP   Ralstonia solanacearum iron scavenging by the siderophore staphyloferrin B is controlled by PhcA, the global virulence regulator.   J Bacteriol. 2004 Dec;186(23):7896-904.  PMID 15547261
Gene Ontology TermGO:0015891: siderophore transport (biological_process)
GO:0015891: siderophore transport (biological_process)
GO:0015891: siderophore transport (biological_process)
GO:0019290: siderophore biosynthetic process (biological_process)
GO:0019290: siderophore biosynthetic process (biological_process)
GO:0019290: siderophore biosynthetic process (biological_process)
GO:0015891: siderophore transport (biological_process)
GO:0015891: siderophore transport (biological_process)
GO:0015891: siderophore transport (biological_process)
GO:0019290: siderophore biosynthetic process (biological_process)
GO:0019290: siderophore biosynthetic process (biological_process)
GO:0019290: siderophore biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
staphylobactin biosynthesis enzyme SbnAsbnAYES2226 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnAsbnAYES2226 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnBsbnBYES2227 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnBsbnBYES2227 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnCsbnCYES2228 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnCsbnCYES2228 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin exporter SbnDsbnDYES2229 (RULE_BASE)
GO:0015891: siderophore transport
staphylobactin exporter SbnDsbnDYES2229 (RULE_BASE)
GO:0015891: siderophore transport
staphylobactin biosynthesis enzyme SbnEsbnEYES2225 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnEsbnEYES2225 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnFsbnFYES2230 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnFsbnFYES2230 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnGsbnGYES2231 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnGsbnGYES2231 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnHsbnHYES2232 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis enzyme SbnHsbnHYES2232 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis operon protein SbnIsbnINO2233 (RULE_BASE)
GO:0019290: siderophore biosynthetic process
staphylobactin biosynthesis operon protein SbnIsbnINO2233 (RULE_BASE)
GO:0019290: siderophore biosynthetic process

Parent Properties
AccessionName
GenProp0770siderophore biosynthesis
GenProp0770siderophore biosynthesis


Sibling Properties
AccessionName
GenProp0771enterobactin (enterochelin) biosynthesis
GenProp0772yersiniabactin biosynthesis
GenProp0773aerobactin biosynthesis
GenProp0775mycobactin biosynthesis
GenProp0776pyochelin biosynthesis
GenProp0783petrobactin biosynthesis