Genome Property Definition Page

Namecarbon fixation via 3-hydroxypropionate and 4-hydroxybutyrate
DescriptionThis fifth discovered carbon assimilation pathway is found mainly in Archaea and consists of a cycle of 16 steps in which two molecules of carbonate are consumed and one molecule of acetyl-CoA is produced. The acetyl-CoA pruduced is further condensed with another molecule of carbon dioxide to form pyruvate. To the point of pyruvate four molecules of ATP are converted to two ADPs and two AMPs, and five molecules NADPH and two molecules of ferredoxin are oxidized while one molecule of NAD+ is reduced.
Parent PropertyGenProp0865: carbon fixation

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
acetyl-CoA carboxylase1YES
succinyl-CoA reductase (NADPH)10YES
succinate semialdehyde reductase (NADPH)11YES
4-hydroxybutyryl-CoA synthetase (AMP-forming)12YES
4-hydroxybutyryl-CoA dehydratase13YES
crotonyl-CoA hydratase14YES
3-hydroxybutyryl-CoA dehydrogenase (NAD+)15YES
acetoacetyl-CoA beta-ketothiolase16YES
pyruvate synthase17NO
acetyl-CoA carboxylase, subunit b1bYES
acetyl-CoA carboxylase, subunit c1cYES
malonyl-CoA reductase2YES
malonate semialdehyde reductase (NADPH)3YES
3-hydroxypropionyl-CoA synthetase (AMP-forming)4YES
3-hydroxypropionyl-CoA dehydratase5YES
acryloyl-CoA reductase (NADPH)6YES
propionyl-CoA carboxylase7YES
propionyl-CoA carboxylase, subunit b7bYES
propionyl-CoA carboxylase, subunit c7cYES
methylmalonyl-CoA epimerase8YES
methylmalonyl-CoA mutase9YES
methylmalonyl-CoA mutase, subunit b9bYES

Parent Properties
GenProp0865carbon fixation

Sibling Properties
GenProp0035Calvin cycle