Genome Property Definition Page

AccessionGenProp0788
Namelysine biosynthesis via diaminopimelate (DAP) utilizing ammonia and NADPH
TypeMETAPATH
DescriptionThis pathway for the biosynthesis of L-lysine differs from the more common diaminopimelate pathway by the action of diaminopimelate dehydrogenase (ddh). This enzyme requires both ammonia as a nitrogen source (instead of an amino acid via a transaminase) and reductive power in the form of NADPH. Additionally, this pathway does not require the acetyl/succinyl protecting group transformations found in the standard pathway, nor does it require the action of diaminopimelate epimerase. This enzyme has been best characterized in Corynebacterium glutamicum and Bacillus sphaericus. One should note that the ddh enzyme is shown acting on the compound L-2-amino-6-oxoheptanedioate in EC and KEGG representations. This is merely the ring-opened form of 2,3,4,5-tetrahydropicolinate with which it is in equilibrium, and upon which the acyltransferases of the common pathway act.
Parent PropertyGenProp0199: lysine biosynthesis
GenProp0199: lysine biosynthesis
GenProp0199: lysine biosynthesis
Literature References
[ 1 ] Schrumpf B, Schwarzer A, Kalinowski J, Puhler A, Eggeling L, Sahm H   A functionally split pathway for lysine synthesis in Corynebacterium glutamicium.   J Bacteriol. 1991 Jul;173(14):4510-6.  PMID 1906065
[ 2 ]  Lysine biosynthesis III:MetaCyc    PMID
[ 1 ] Schrumpf B, Schwarzer A, Kalinowski J, Puhler A, Eggeling L, Sahm H   A functionally split pathway for lysine synthesis in Corynebacterium glutamicium.   J Bacteriol. 1991 Jul;173(14):4510-6.  PMID 1906065
[ 2 ]  Lysine biosynthesis III:MetaCyc    PMID
[ 1 ] Schrumpf B, Schwarzer A, Kalinowski J, Puhler A, Eggeling L, Sahm H   A functionally split pathway for lysine synthesis in Corynebacterium glutamicium.   J Bacteriol. 1991 Jul;173(14):4510-6.  PMID 1906065
[ 2 ]  Lysine biosynthesis III:MetaCyc    PMID
Web ReferencesLysine biosynthesis:KEGG
Lysine biosynthesis:KEGG
Lysine biosynthesis:KEGG
Gene Ontology TermGO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (biological_process)
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (biological_process)
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (biological_process)
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (biological_process)
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (biological_process)
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (biological_process)
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (biological_process)
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (biological_process)
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
Source of aspartate-semialdehydeAsp-SAYESGenProp0160 (GENPROP): aspartate semialdehyde biosynthesis from aspartate
GenProp0160 (GENPROP): aspartate semialdehyde biosynthesis from aspartate
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
Source of aspartate-semialdehydeAsp-SAYESGenProp0160 (GENPROP): aspartate semialdehyde biosynthesis from aspartate
GenProp0160 (GENPROP): aspartate semialdehyde biosynthesis from aspartate
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
Source of aspartate-semialdehydeAsp-SAYESGenProp0160 (GENPROP): aspartate semialdehyde biosynthesis from aspartate
GenProp0160 (GENPROP): aspartate semialdehyde biosynthesis from aspartate
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
diaminopimelate decarboxylaseDAPDCYESTIGR01048 (HMM): diaminopimelate decarboxylase
TIGR01048 (HMM): diaminopimelate decarboxylase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
diaminopimelate decarboxylaseDAPDCYESTIGR01048 (HMM): diaminopimelate decarboxylase
TIGR01048 (HMM): diaminopimelate decarboxylase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
diaminopimelate decarboxylaseDAPDCYESTIGR01048 (HMM): diaminopimelate decarboxylase
TIGR01048 (HMM): diaminopimelate decarboxylase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
dihydrodipicolinate reductaseDHPRYESTIGR00036 (HMM): 4-hydroxy-tetrahydrodipicolinate reductase
TIGR00036 (HMM): 4-hydroxy-tetrahydrodipicolinate reductase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
dihydrodipicolinate reductaseDHPRYESTIGR00036 (HMM): 4-hydroxy-tetrahydrodipicolinate reductase
TIGR00036 (HMM): 4-hydroxy-tetrahydrodipicolinate reductase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
dihydrodipicolinate reductaseDHPRYESTIGR00036 (HMM): 4-hydroxy-tetrahydrodipicolinate reductase
TIGR00036 (HMM): 4-hydroxy-tetrahydrodipicolinate reductase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
dihydrodipicolinate synthaseDHPSYESTIGR00674 (HMM): 4-hydroxy-tetrahydrodipicolinate synthase
TIGR00674 (HMM): 4-hydroxy-tetrahydrodipicolinate synthase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
dihydrodipicolinate synthaseDHPSYESTIGR00674 (HMM): 4-hydroxy-tetrahydrodipicolinate synthase
TIGR00674 (HMM): 4-hydroxy-tetrahydrodipicolinate synthase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
dihydrodipicolinate synthaseDHPSYESTIGR00674 (HMM): 4-hydroxy-tetrahydrodipicolinate synthase
TIGR00674 (HMM): 4-hydroxy-tetrahydrodipicolinate synthase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
diaminopimelate dehydrogenaseddhYESTIGR01921 (HMM): diaminopimelate dehydrogenase
TIGR01921 (HMM): diaminopimelate dehydrogenase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
diaminopimelate dehydrogenaseddhYESTIGR01921 (HMM): diaminopimelate dehydrogenase
TIGR01921 (HMM): diaminopimelate dehydrogenase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
diaminopimelate dehydrogenaseddhYESTIGR01921 (HMM): diaminopimelate dehydrogenase
TIGR01921 (HMM): diaminopimelate dehydrogenase
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway

Parent Properties
AccessionName
GenProp0199lysine biosynthesis
GenProp0199lysine biosynthesis
GenProp0199lysine biosynthesis


Sibling Properties
AccessionName
GenProp0125lysine biosynthesis via diaminopimelate (DAP)
GenProp0193lysine biosynthesis via alpha-aminoadipate (AAA pathway)