Accession | GenProp0788 |
Name | lysine biosynthesis via diaminopimelate (DAP) utilizing ammonia and NADPH |
Type | METAPATH |
Description | This pathway for the biosynthesis of L-lysine differs from the more common diaminopimelate pathway by the action of diaminopimelate dehydrogenase (ddh). This enzyme requires both ammonia as a nitrogen source (instead of an amino acid via a transaminase) and reductive power in the form of NADPH. Additionally, this pathway does not require the acetyl/succinyl protecting group transformations found in the standard pathway, nor does it require the action of diaminopimelate epimerase. This enzyme has been best characterized in Corynebacterium glutamicum and Bacillus sphaericus.
One should note that the ddh enzyme is shown acting on the compound L-2-amino-6-oxoheptanedioate in EC and KEGG representations. This is merely the ring-opened form of 2,3,4,5-tetrahydropicolinate with which it is in equilibrium, and upon which the acyltransferases of the common pathway act. |
Parent Property | GenProp0199: lysine biosynthesis
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Literature References | [ 1 ] Schrumpf B, Schwarzer A, Kalinowski J, Puhler A, Eggeling L, Sahm H A functionally split pathway for lysine synthesis in Corynebacterium glutamicium. J Bacteriol. 1991 Jul;173(14):4510-6. PMID 1906065 [ 2 ] Lysine biosynthesis III:MetaCyc PMID |
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Web References | Lysine biosynthesis:KEGG |
Gene Ontology Term | GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (biological_process)
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Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
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Source of aspartate-semialdehyde | Asp-SA | YES | GenProp0160 (GENPROP): aspartate semialdehyde biosynthesis from aspartate
| GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
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diaminopimelate decarboxylase | DAPDC | YES | TIGR01048 (HMM): diaminopimelate decarboxylase | GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
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dihydrodipicolinate reductase | DHPR | YES | TIGR00036 (HMM): 4-hydroxy-tetrahydrodipicolinate reductase | GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
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dihydrodipicolinate synthase | DHPS | YES | TIGR00674 (HMM): 4-hydroxy-tetrahydrodipicolinate synthase | GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
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diaminopimelate dehydrogenase | ddh | YES | TIGR01921 (HMM): diaminopimelate dehydrogenase | GO:0033361: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
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