Genome Property Definition Page

AccessionGenProp0793
NameCMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine
TypeMETAPATH
DescriptionCMP-N5-acetylneuraminate (CMP-Neu5Ac) is the activated version of a sugar unit found in certain glycolipids and glycoproteins. Neuraminic acid is also commonly known as sialic acid. In particular, Neu5Ac is observed in certain versions of the E. coli O-antigen [1]. CMP-Neu5Ac is synthesized in three steps: isomerization of UDP-GlcNAc to N-Acetyl-D-Mannosamine (ManNAc) catalyzed by NeuC (5.1.3.14), a condensation with phosphoenolpyruvate to form NeuNAc catalyzed by NeuB (2.5.1.56) and an activation with CTPcatalyzed by NeuA (2.7.7.43). A fourth gene product, NeuD is believed to carry out O-acetyltransfers onto sialic acid but is often missing and is also found more broadly than NeuABC
Parent PropertyGenProp0186: storage and structural polymer biosynthesis
GenProp0795: carbohydrate biosynthesis
GenProp0186: storage and structural polymer biosynthesis
GenProp0795: carbohydrate biosynthesis
GenProp0186: storage and structural polymer biosynthesis
GenProp0795: carbohydrate biosynthesis
Literature References
[ 1 ] Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L   Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.   J Bacteriol. 2005 Jan;187(2):758-64.  PMID 15629947
[ 1 ] Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L   Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.   J Bacteriol. 2005 Jan;187(2):758-64.  PMID 15629947
[ 1 ] Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L   Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.   J Bacteriol. 2005 Jan;187(2):758-64.  PMID 15629947
Web ReferencesKEGG:Aminosugars Metabolism
KEGG:Aminosugars Metabolism
KEGG:Aminosugars Metabolism
Gene Ontology TermGO:0006054: N-acetylneuraminate metabolic process (biological_process)
GO:0006054: N-acetylneuraminate metabolic process (biological_process)
GO:0006054: N-acetylneuraminate metabolic process (biological_process)
GO:0006054: N-acetylneuraminate metabolic process (biological_process)
GO:0006054: N-acetylneuraminate metabolic process (biological_process)
GO:0006054: N-acetylneuraminate metabolic process (biological_process)
GO:0006054: N-acetylneuraminate metabolic process (biological_process)
GO:0006054: N-acetylneuraminate metabolic process (biological_process)
GO:0006054: N-acetylneuraminate metabolic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
CTP:N-acylneuraminate cytidyltransferase (2.7.7.43)NeuAYESPF02348 (HMM-CLUST): cytidylyltransferase
PF02348 (HMM-CLUST): cytidylyltransferase
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
CTP:N-acylneuraminate cytidyltransferase (2.7.7.43)NeuAYESPF02348 (HMM-CLUST): cytidylyltransferase
PF02348 (HMM-CLUST): cytidylyltransferase
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
CTP:N-acylneuraminate cytidyltransferase (2.7.7.43)NeuAYESPF02348 (HMM-CLUST): cytidylyltransferase
PF02348 (HMM-CLUST): cytidylyltransferase
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
N-acetylneuraminate synthase (2.5.1.56)NeuBYESTIGR03569 (HMM): N-acetylneuraminate synthase
TIGR03569 (HMM): N-acetylneuraminate synthase
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
N-acetylneuraminate synthase (2.5.1.56)NeuBYESTIGR03569 (HMM): N-acetylneuraminate synthase
TIGR03569 (HMM): N-acetylneuraminate synthase
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
N-acetylneuraminate synthase (2.5.1.56)NeuBYESTIGR03569 (HMM): N-acetylneuraminate synthase
TIGR03569 (HMM): N-acetylneuraminate synthase
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysingNeuCYESTIGR03568 (HMM): UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
TIGR03568 (HMM): UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysingNeuCYESTIGR03568 (HMM): UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
TIGR03568 (HMM): UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysingNeuCYESTIGR03568 (HMM): UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
TIGR03568 (HMM): UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
sialic acid O-acetyltransferase NeuDNeuDNOTIGR03570 (HMM-CLUST): sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
TIGR03570 (HMM-CLUST): sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
sialic acid O-acetyltransferase NeuDNeuDNOTIGR03570 (HMM-CLUST): sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
TIGR03570 (HMM-CLUST): sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
sialic acid O-acetyltransferase NeuDNeuDNOTIGR03570 (HMM-CLUST): sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
TIGR03570 (HMM-CLUST): sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
source of UDP-N-acetyl-D-glucosamineUGlcNAcNOGenProp0750 (GENPROP): UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GenProp0750 (GENPROP): UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
source of UDP-N-acetyl-D-glucosamineUGlcNAcNOGenProp0750 (GENPROP): UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GenProp0750 (GENPROP): UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process
source of UDP-N-acetyl-D-glucosamineUGlcNAcNOGenProp0750 (GENPROP): UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GenProp0750 (GENPROP): UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GO:0006054: N-acetylneuraminate metabolic process
GO:0006054: N-acetylneuraminate metabolic process

Parent Properties
AccessionName
GenProp0186storage and structural polymer biosynthesis
GenProp0795carbohydrate biosynthesis
GenProp0186storage and structural polymer biosynthesis
GenProp0795carbohydrate biosynthesis
GenProp0186storage and structural polymer biosynthesis
GenProp0795carbohydrate biosynthesis


Sibling Properties
AccessionName
GenProp0055polyhydroxyalkanoic acids
GenProp0156cyanophycin-like storage polymers
GenProp0158peptidoglycan(murein) biosynthesis
GenProp0168glycogen system
GenProp0183dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose
GenProp0297lipopolysaccharide biosynthesis
GenProp0652exopolysaccharide biosynthesis, exosortase A-associated
GenProp0655exopolysaccharide biosynthesis, exosortase B-associated
GenProp0658cellulose biosynthesis
GenProp0822poly(gamma-glutamic acid) biosynthesis
GenProp0906poly-beta-1,6 N-acetyl-D-glucosamine system, IcaADBC type
GenProp0907poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type
GenProp0264glucosylglycerol biosynthesis
GenProp0750UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GenProp0766anhydro-N-acetylmuramic acid to N-acetylglucosamine-phosphate
GenProp0794proposed N-acetyl sugar amidation module WbuXYZ
GenProp0796CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine
GenProp0811S-layer homology domain-mediated cell wall binding