Genome Property Definition Page

AccessionGenProp0823
Nameviolacein biosynthesis
TypePATHWAY
DescriptionViolacein is a purple bisindole toxin derived from a pair of tryptophan residues, made by bacteria that include Chromobacterium violaceum ATCC 12472, Janthinobacterium lividum, and Pseudoalteromonas tunicata. The first two steps are shared with pathways for indolocarbazoles (rebeccamycin, staurosporine), but action by VioE at the third step produces protodeoxyviolaceinic acid, rather than allowing the non-enzymatic conversion to chromopyrrolic acid that occurs during staurosporine biosynthesis. VioE therefore is a good marker for the biosynthesis of violacein or closely related compounds.
JCVI RoleToxin production and resistance
Parent PropertyGenProp0077: natural products biosynthesis
Literature References
[ 1 ] Hirano S, Asamizu S, Onaka H, Shiro Y, Nagano S   Crystal structure of VioE, a key player in the construction of the molecular skeleton of violacein.   J Biol Chem. 2008 Mar 7;283(10):6459-66  PMID 18171677

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
violacein biosynthesis monooxygenase VioCvioCYES2336 (RULE_BASE)
violacein biosynthesis enzyme VioDvioDYES2337 (RULE_BASE)
violacein biosynthesis enzyme VioEvioEYESTIGR03650 (HMM): violacein biosynthesis enzyme VioE

Parent Properties
AccessionName
GenProp0077natural products biosynthesis


Sibling Properties
AccessionName
GenProp0014polyketide biosynthesis, type I
GenProp0015polyketide biosynthesis, type II
GenProp0040thiotemplate type non-ribosomal peptide biosynthesis
GenProp0169hybrid NRPS-PKS natural pruduct biosynthesis genes
GenProp0724phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate
GenProp0757quorum-sensing, autoinducer-2 system
GenProp0758lycopene biosynthesis from IPP
GenProp0770siderophore biosynthesis
GenProp0807bacteriocin system, heterocycle biosynthesis group
GenProp0808bacteriocin system, TIGR01847 leader group
GenProp0809bacteriocin system, lactococcin 972 group
GenProp0810bacteriocin system, linocin M18 group
GenProp0825bacteriocin system, circular bacteriocin group
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0861bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group
GenProp0901post-ribosomal natural product synthesis system, Burkholderia TOMM-type
GenProp0919SCIFF/radical SAM Clostridial gene pair
GenProp0920radical SAM Y_X(10)_GDL system
GenProp0921radical SAM pair and His-Xaa-Ser repeats peptide
GenProp0936bacteriocin system, sporulation delay protein group
GenProp0945radical SAM maturase bacteriocin system, CLI_3235 type
GenProp0954radical SAM-cylized peptide, Pep1357C family
GenProp0955modified peptide/radical SAM maturase system, YydFG family
GenProp0956radical SAM maturase/selenobacteriocin system
GenProp0962methanobactin biosynthesis, Mb-OB3b family
GenProp0967radical SAM maturase system, CXXX repeats type
GenProp0982radical SAM maturase system, FibroRumin system
GenProp0984radical SAM maturase system, GG-Bacteroidales group
GenProp0990cobaltopeptin biosynthesis
GenProp0991ATP-grasp maturase system, microviridin/marinostatin class
GenProp1000ATP-grasp maturase system, uncharacterized
GenProp1002grasp-with-spasm peptide maturase system
GenProp1003cysteine S-glycopeptide biosynthesis, sublancin family
GenProp1029radical SAM/SPASM system SynChlorMet
GenProp1037radical SAM/SPASM system GRRM
GenProp1052geopeptide radical SAM/SPASM maturase system
GenProp1062radical SAM/SPASM system Clo7bot
GenProp1065radical SAM/SPASM TIGR04347/TIGR04031 system
GenProp1078sporulation killing factor system
GenProp1083cyanobactin-like ribosomal natural product biosynthesis
GenProp1084enduracididine biosynthesis
GenProp1090radical SAM/SPASM maturase system XYE