Genome Property Definition Page

Namebacteriocin system, circular bacteriocin group
DescriptionThis Genome Property describes a class of bacteriocin in which polypeptide produced on a ribosome is circularized. Within this Property are several non-homologous subgroups, described by different protein family signatures. Many bacteriocins are described as cyclic, but this subclass is distinguished by having the N-terminal and C-terminal amino acids linked from a precursor translated on a ribosome. They tend to be produced by Gram-positive bacteria, and to have less post-translational modification than the lantibiotic class of bacteriocin. Members of this subclass of the circular bacteriocins include circularin A from Clostridium beijerinckii, bacteriocin AS-48 from Enterococcus faecalis, uberolysin from Streptococcus uberis, and carnocyclin A from Carnobacterium maltaromaticum.
JCVI RoleToxin production and resistance
Parent PropertyGenProp0077: natural products biosynthesis
Literature References
[ 1 ] Maqueda M, Sanchez-Hidalgo M, Fernandez M, Montalban-Lopez M, Valdivia E, Martinez-Bueno M   Genetic features of circular bacteriocins produced by Gram-positive bacteria.   FEMS Microbiol Rev. 2008 Jan;32(1):2-22. Epub 2007 Nov 20.  PMID 18034824
Gene Ontology TermGO:0030152: bacteriocin biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
circular bacteriocinactiveYESTIGR03651 (HMM): circular bacteriocin, circularin A/uberolysin family
2339 (RULE_BASE)

2340 (RULE_BASE)
GO:0030152: bacteriocin biosynthetic process
GO:0030152: bacteriocin biosynthetic process
GO:0030152: bacteriocin biosynthetic process

Parent Properties
GenProp0077natural products biosynthesis

Sibling Properties
GenProp0014polyketide biosynthesis, type I
GenProp0015polyketide biosynthesis, type II
GenProp0040thiotemplate type non-ribosomal peptide biosynthesis
GenProp0169hybrid NRPS-PKS natural pruduct biosynthesis genes
GenProp0724phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate
GenProp0757quorum-sensing, autoinducer-2 system
GenProp0758lycopene biosynthesis from IPP
GenProp0770siderophore biosynthesis
GenProp0807bacteriocin system, heterocycle biosynthesis group
GenProp0808bacteriocin system, TIGR01847 leader group
GenProp0809bacteriocin system, lactococcin 972 group
GenProp0823violacein biosynthesis
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0861bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group
GenProp0901post-ribosomal natural product synthesis system, Burkholderia TOMM-type
GenProp0919SCIFF/radical SAM Clostridial gene pair
GenProp0920radical SAM Y_X(10)_GDL system
GenProp0921radical SAM pair and His-Xaa-Ser repeats peptide
GenProp0936bacteriocin system, sporulation delay protein group
GenProp0945radical SAM maturase bacteriocin system, CLI_3235 type
GenProp0954radical SAM-cylized peptide, Pep1357C family
GenProp0955modified peptide/radical SAM maturase system, YydFG family
GenProp0956radical SAM maturase/selenobacteriocin system
GenProp0962methanobactin biosynthesis, Mb-OB3b family
GenProp0967radical SAM maturase system, CXXX repeats type
GenProp0982radical SAM maturase system, FibroRumin system
GenProp0984radical SAM maturase system, GG-Bacteroidales group
GenProp0990cobaltopeptin biosynthesis
GenProp0991ATP-grasp maturase system, microviridin/marinostatin class
GenProp1000ATP-grasp maturase system, uncharacterized
GenProp1002grasp-with-spasm peptide maturase system
GenProp1003cysteine S-glycopeptide biosynthesis, sublancin family
GenProp1029radical SAM/SPASM system SynChlorMet
GenProp1037radical SAM/SPASM system GRRM
GenProp1052geopeptide radical SAM/SPASM maturase system
GenProp1062radical SAM/SPASM system Clo7bot
GenProp1065radical SAM/SPASM TIGR04347/TIGR04031 system
GenProp1078sporulation killing factor system
GenProp1083cyanobactin-like ribosomal natural product biosynthesis
GenProp1084enduracididine biosynthesis
GenProp1090radical SAM/SPASM maturase system XYE
GenProp1097bacimethrin biosynthesis
GenProp10983-methylarginine biosynthesis