Genome Property Definition Page
| Accession | GenProp0833 | |
| Name | proteasome-targeting modification by pupylation | |
| Type | SYSTEM | |
| Description | Pupylation is the process by which the small protein Pup is conjugated to proteins through its C-terminus to a lysine epsilon-amino group of the target. This modification, analogous to ubiquitination in eukaryotes, targets proteins for degradation by archaeal-type proteasomes in Mycobacterium tuberculosis and related Actinobacteria. | |
| JCVI Role | Degradation of proteins, peptides, and glycopeptides | |
| Parent Property | GenProp0301: protein degradation | |
| Literature References |
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| Gene Ontology Term | GO:0019941: modification-dependent protein catabolic process (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| 20S proteasome | PROSOME | YES | GenProp0834 (GENPROP): proteasome, bacterial | GO:0019941: modification-dependent protein catabolic process |
| ubiquitin-like protein Pup | pup | YES | TIGR03687 (HMM): ubiquitin-like protein Pup | GO:0019941: modification-dependent protein catabolic process |
| AAA family ATPase, pupylation-associated | pup_AAA | YES | TIGR03689 (HMM): proteasome ATPase | GO:0019941: modification-dependent protein catabolic process |
| Pup ligase | pup_lig | YES | TIGR03686 (HMM): proteasome accessory factor PafA TIGR03688 (HMM): proteasome accessory factor PafA2 | GO:0019941: modification-dependent protein catabolic process GO:0019941: modification-dependent protein catabolic process |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0301 | protein degradation |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0211 | tmRNA trans-translation system |
| GenProp0251 | clpXP degradation machine |
| GenProp0684 | FtsH/HflKC protease complex |
| GenProp0834 | proteasome, bacterial |
| GenProp0835 | ATP-dependent protease HslVU |