Genome Property Definition Page

AccessionGenProp0848
Nameactin-based motility of invasive bacteria
TypeSYSTEM
DescriptionActin-based motility is the process by which a bacterial pathogen uses host cell actin dynamics to achieve movement within or between cells. Bacteria known to have this capacity include Mycobacterium marinum, Burkholderia pseudomallei, and and Listeria, Rickettsia, and Shigella species. Proteins responsible for actin-dependent movement in different species share actin-binding function but may have no sequence homology from one to another.
JCVI RolePathogenesis
Parent PropertyGenProp0073: cell motility
GenProp0073: cell motility
GenProp0073: cell motility
Literature References
[ 1 ] Gouin E, Welch MD, Cossart P   Actin-based motility of intracellular pathogens.   Curr Opin Microbiol. 2005 Feb;8(1):35-45.  PMID 15694855
[ 2 ] Stevens JM, Galyov EE, Stevens MP   Actin-dependent movement of bacterial pathogens.   Nat Rev Microbiol. 2006 Feb;4(2):91-101.  PMID 16415925
[ 3 ] Kocks C, Marchand JB, Gouin E, d'Hauteville H, Sansonetti PJ, Carlier MF, Cossart P   The unrelated surface proteins ActA of Listeria monocytogenes and IcsA of Shigella flexneri are sufficient to confer actin-based motility on Listeria innocua and Escherichia coli respectively.   Mol Microbiol. 1995 Nov;18(3):413-23.  PMID 8748026
[ 1 ] Gouin E, Welch MD, Cossart P   Actin-based motility of intracellular pathogens.   Curr Opin Microbiol. 2005 Feb;8(1):35-45.  PMID 15694855
[ 2 ] Stevens JM, Galyov EE, Stevens MP   Actin-dependent movement of bacterial pathogens.   Nat Rev Microbiol. 2006 Feb;4(2):91-101.  PMID 16415925
[ 3 ] Kocks C, Marchand JB, Gouin E, d'Hauteville H, Sansonetti PJ, Carlier MF, Cossart P   The unrelated surface proteins ActA of Listeria monocytogenes and IcsA of Shigella flexneri are sufficient to confer actin-based motility on Listeria innocua and Escherichia coli respectively.   Mol Microbiol. 1995 Nov;18(3):413-23.  PMID 8748026
[ 1 ] Gouin E, Welch MD, Cossart P   Actin-based motility of intracellular pathogens.   Curr Opin Microbiol. 2005 Feb;8(1):35-45.  PMID 15694855
[ 2 ] Stevens JM, Galyov EE, Stevens MP   Actin-dependent movement of bacterial pathogens.   Nat Rev Microbiol. 2006 Feb;4(2):91-101.  PMID 16415925
[ 3 ] Kocks C, Marchand JB, Gouin E, d'Hauteville H, Sansonetti PJ, Carlier MF, Cossart P   The unrelated surface proteins ActA of Listeria monocytogenes and IcsA of Shigella flexneri are sufficient to confer actin-based motility on Listeria innocua and Escherichia coli respectively.   Mol Microbiol. 1995 Nov;18(3):413-23.  PMID 8748026
Gene Ontology TermGO:0070358: actin polymerization-dependent cell motility (biological_process)
GO:0070358: actin polymerization-dependent cell motility (biological_process)
GO:0070358: actin polymerization-dependent cell motility (biological_process)
GO:0070358: actin polymerization-dependent cell motility (biological_process)
GO:0070358: actin polymerization-dependent cell motility (biological_process)
GO:0070358: actin polymerization-dependent cell motility (biological_process)
GO:0070358: actin polymerization-dependent cell motility (biological_process)
GO:0070358: actin polymerization-dependent cell motility (biological_process)
GO:0070358: actin polymerization-dependent cell motility (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
actin-based motility proteinactinYESPF05058 (HMM): protein ActA
2401 (RULE_BASE)

2371 (RULE_BASE)

PF05058 (HMM): protein ActA
2401 (RULE_BASE)

2371 (RULE_BASE)
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
actin-based motility proteinactinYESPF05058 (HMM): protein ActA
2401 (RULE_BASE)

2371 (RULE_BASE)

PF05058 (HMM): protein ActA
2401 (RULE_BASE)

2371 (RULE_BASE)
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
actin-based motility proteinactinYESPF05058 (HMM): protein ActA
2401 (RULE_BASE)

2371 (RULE_BASE)

PF05058 (HMM): protein ActA
2401 (RULE_BASE)

2371 (RULE_BASE)
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility

Parent Properties
AccessionName
GenProp0073cell motility
GenProp0073cell motility
GenProp0073cell motility


Sibling Properties
AccessionName
GenProp0007flagella
GenProp0026chemotaxis
GenProp0056type IV pilus
GenProp0781gliding motility, Bacteroidetes type