Genome Property Definition Page

Nameactin-based motility of invasive bacteria
DescriptionActin-based motility is the process by which a bacterial pathogen uses host cell actin dynamics to achieve movement within or between cells. Bacteria known to have this capacity include Mycobacterium marinum, Burkholderia pseudomallei, and and Listeria, Rickettsia, and Shigella species. Proteins responsible for actin-dependent movement in different species share actin-binding function but may have no sequence homology from one to another.
JCVI RolePathogenesis
Parent PropertyGenProp0073: cell motility
Literature References
[ 1 ] Gouin E, Welch MD, Cossart P   Actin-based motility of intracellular pathogens.   Curr Opin Microbiol. 2005 Feb;8(1):35-45.  PMID 15694855
[ 2 ] Stevens JM, Galyov EE, Stevens MP   Actin-dependent movement of bacterial pathogens.   Nat Rev Microbiol. 2006 Feb;4(2):91-101.  PMID 16415925
[ 3 ] Kocks C, Marchand JB, Gouin E, d'Hauteville H, Sansonetti PJ, Carlier MF, Cossart P   The unrelated surface proteins ActA of Listeria monocytogenes and IcsA of Shigella flexneri are sufficient to confer actin-based motility on Listeria innocua and Escherichia coli respectively.   Mol Microbiol. 1995 Nov;18(3):413-23.  PMID 8748026
Gene Ontology TermGO:0070358: actin polymerization-dependent cell motility (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
actin-based motility proteinactinYESPF05058 (HMM): protein ActA
2401 (RULE_BASE)

2371 (RULE_BASE)
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility
GO:0070358: actin polymerization-dependent cell motility

Parent Properties
GenProp0073cell motility

Sibling Properties
GenProp0056type IV pilus
GenProp0781gliding motility, Bacteroidetes type