Genome Property Definition Page

Namedecarboxylation/antiport proton-motive cycle: aspartate-alanine
DescriptionThis Genome Property represents a proton-motive cycle. A cycle of decarboxylating an aspartate to alanine plus CO2, then exchanging the cytosolic alanine for an extracellular asparate, has the net effect of consuming one proton. Analogous systems for antiport of substrates related by decarboxylation include, for example, the pairing of an acid-induced arginine decarboxylase with an arginine-agmatine antiporter as in Escherichia coli.
Parent PropertyGenProp0873: ion-motive antiporter cycles
GenProp0874: response to acid (low pH) environment
Literature References
[ 1 ] Abe K, Ohnishi F, Yagi K, Nakajima T, Higuchi T, Sano M, Machida M, Sarker RI, Maloney PC   Plasmid-encoded asp operon confers a proton motive metabolic cycle catalyzed by an aspartate-alanine exchange reaction.   J Bacteriol. 2002 Jun;184(11):2906-13.  PMID 12003930
Gene Ontology TermGO:0010248: establishment or maintenance of transmembrane electrochemical gradient (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
aspartate 4-decarboxylaseAspDYESTIGR03801 (HMM): aspartate 4-decarboxylaseGO:0010248: establishment or maintenance of transmembrane electrochemical gradient
aspartate-alanine antiporterAspTYESTIGR03802 (HMM): aspartate-alanine antiporterGO:0010248: establishment or maintenance of transmembrane electrochemical gradient

Parent Properties
GenProp0873ion-motive antiporter cycles
GenProp0874response to acid (low pH) environment

Sibling Properties
GenProp0639arginine degradation via citrulline, ATP-generating
GenProp0869decarboxylation/antiport proton-motive cycle: arginine-agmatine
GenProp0870decarboxylation/antiport proton-motive cycle: lysine-cadaverine
GenProp0871decarboxylation/antiport proton-motive cycle: ornithine-putrescine
GenProp0872decarboxylation/antiport proton-motive cycle: histidine-histamine
GenProp0875decarboxylation/antiport proton-motive cycle: tyrosine-tyramine
GenProp0876decarboxylation/antiport proton-motive cycle: glutamate-GABA
GenProp1034decarboxylation/antiport proton-motive cycle: oxalate-formate