Genome Property Definition Page

NameN(epsilon)-acetyl-beta-lysine biosynthesis
DescriptionN(epsilon)-acetyl-beta-lysine is a compatible solute produced in methanogenic archaea under salt stress. Note that the first enzyme in this two-step pathway can instead serve as the first step in lysine catabolism, as in Clostridium subterminale SB4 (see PMID:10629195).
JCVI RoleAdaptations to atypical conditions
Parent PropertyGenProp0267: osmolyte biosynthesis
Literature References
[ 1 ] Pfluger K, Baumann S, Gottschalk G, Lin W, Santos H, Muller V   Lysine-2,3-aminomutase and beta-lysine acetyltransferase genes of methanogenic archaea are salt induced and are essential for the biosynthesis of Nepsilon-acetyl-beta-lysine and growth at high salinity.   Appl Environ Microbiol. 2003 Oct;69(10):6047-55.  PMID 14532061
Gene Ontology TermGO:0042398: cellular modified amino acid biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
lysine-2,3-aminomutaseablAYESTIGR03820 (HMM): lysine-2,3-aminomutaseGO:0042398: cellular modified amino acid biosynthetic process
beta-lysine acetyltransferaseablBYESTIGR03827 (HMM): putative beta-lysine N-acetyltransferaseGO:0042398: cellular modified amino acid biosynthetic process

Parent Properties
GenProp0267osmolyte biosynthesis

Sibling Properties
GenProp0147glycine betaine biosynthesis from choline
GenProp0264glucosylglycerol biosynthesis
GenProp0265trehalose biosynthesis, OtsAB pathway
GenProp0266trehalose biosynthesis, TreYZ pathway
GenProp0268ectoine biosynthesis
GenProp0281mannosylglycerate biosynthesis
GenProp1070beta-glutamate biosynthesis