Accession | GenProp0902 |
Name | quinohemoprotein amine dehydrogenase |
Type | SYSTEM |
Description | This system is characterized by three subunits of the mature enzyme, plus one radical SAM protein involved in modification of the gamma subunit. The gamma subunit contains two unusual modifications. One is a cysteine tryptophylquinone, which unlike PQQ is derived from the polypeptide precursor. The other is intrapeptidyl thioether cross-linking. |
Parent Property | GenProp0142: catabolism
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Literature References | [ 1 ]Ono K, Okajima T, Tani M, Kuroda S, Sun D, Davidson VL, Tanizawa K Involvement of a putative [Fe-S]-cluster-binding protein in the biogenesis of quinohemoprotein amine dehydrogenase. J Biol Chem. 2006 May 12;281(19):13672-84. PMID 16546999 [ 2 ]Satoh A, Kim JK, Miyahara I, Devreese B, Vandenberghe I, Hacisalihoglu A, Okajima T, Kuroda S, Adachi O, Duine JA, Van Beeumen J, Tanizawa K, Hirotsu K Crystal structure of quinohemoprotein amine dehydrogenase from Pseudomonas putida. Identification of a novel quinone cofactor encaged by multiple thioether cross-bridges. J Biol Chem. 2002 Jan 25;277(4):2830-4. PMID 11704672 |
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Gene Ontology Term | GO:0030058: amine dehydrogenase activity (molecular_function) GO:0043687: post-translational protein modification (biological_process)
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Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
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quinohemoprotein amine dehydrogenase maturation protein | QH_SAM | YES | TIGR03906 (HMM): quinohemoprotein amine dehydrogenase maturation protein | GO:0043687: post-translational protein modification
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quinohemoprotein amine dehydrogenase, alpha subunit | QH_alp | YES | TIGR03908 (HMM): quinohemoprotein amine dehydrogenase, alpha subunit | GO:0030058: amine dehydrogenase activity
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quinohemoprotein amine dehydrogenase, beta subunit | QH_bet | YES | TIGR03907 (HMM): quinohemoprotein amine dehydrogenase, beta subunit | GO:0030058: amine dehydrogenase activity
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quinohemoprotein amine dehydrogenase, gamma subunit | QH_gam | YES | PF08992 (HMM): quinohemoprotein amine dehydrogenase, gamma subunit | GO:0030058: amine dehydrogenase activity
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