Genome Property Definition Page

Name2,3-diaminopropionic acid biosynthesis
DescriptionL-2,3-diaminopropionic acid (Dap) is an intermediate in the biosynthesis of a number of metabolites, such as the siderophore staphyloferrin B. Cheung, et al. (2009) cite their own unpublished results that SbnA and SbnB produce Dap. SbnA is a pyridoxal phosphate-dependent enzyme distantly related to diaminopropionate ammonia-lyase. SbnB shows homology to an NAD-dependent alanine dehydrogenase of Archaeoglobus fulgidus. The two occasionally occur as a fusion protein.
Literature References
[ 1 ]Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE  Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.  Mol Microbiol. 2009 Nov;74(3):594-608. Epub 2009 Sep 22.  PMID 19775248

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
2,3-diaminopropionate biosynthesis protein SbnADapSbnAYESTIGR03945 (HMM): 2,3-diaminopropionate biosynthesis protein SbnA
2,3-diaminopropionate biosynthesis protein SbnBDapSbnBYESTIGR03944 (HMM): 2,3-diaminopropionate biosynthesis protein SbnB