Genome Property Definition Page

AccessionGenProp0914
Namehydrogenase, [FeFe]-dependent
TypeSYSTEM
DescriptionThis system consists of two radical SAM proteins and a GTP-binding protein involved in [Fe] hydrogenase maturation.
JCVI RoleProtein modification and repair
Parent PropertyGenProp0070: energy metabolism
GenProp0070: energy metabolism
GenProp0070: energy metabolism
Literature References
[ 1 ]Posewitz MC, King PW, Smolinski SL, Zhang L, Seibert M, Ghirardi ML  Discovery of two novel radical S-adenosylmethionine proteins required for the assembly of an active [Fe] hydrogenase.  J Biol Chem. 2004 Jun 11;279(24):25711-20. Epub 2004 Apr 13.  PMID 15082711
[ 2 ]Kuchenreuther JM, Stapleton JA, Swartz JR  Tyrosine, cysteine, and S-adenosyl methionine stimulate in vitro [FeFe] hydrogenase activation.  PLoS One. 2009 Oct 26;4(10):e7565.  PMID 19855833
[ 1 ]Posewitz MC, King PW, Smolinski SL, Zhang L, Seibert M, Ghirardi ML  Discovery of two novel radical S-adenosylmethionine proteins required for the assembly of an active [Fe] hydrogenase.  J Biol Chem. 2004 Jun 11;279(24):25711-20. Epub 2004 Apr 13.  PMID 15082711
[ 2 ]Kuchenreuther JM, Stapleton JA, Swartz JR  Tyrosine, cysteine, and S-adenosyl methionine stimulate in vitro [FeFe] hydrogenase activation.  PLoS One. 2009 Oct 26;4(10):e7565.  PMID 19855833
[ 1 ]Posewitz MC, King PW, Smolinski SL, Zhang L, Seibert M, Ghirardi ML  Discovery of two novel radical S-adenosylmethionine proteins required for the assembly of an active [Fe] hydrogenase.  J Biol Chem. 2004 Jun 11;279(24):25711-20. Epub 2004 Apr 13.  PMID 15082711
[ 2 ]Kuchenreuther JM, Stapleton JA, Swartz JR  Tyrosine, cysteine, and S-adenosyl methionine stimulate in vitro [FeFe] hydrogenase activation.  PLoS One. 2009 Oct 26;4(10):e7565.  PMID 19855833
Gene Ontology TermGO:0006464: protein modification process (biological_process)
GO:0006464: protein modification process (biological_process)
GO:0006464: protein modification process (biological_process)
GO:0006464: protein modification process (biological_process)
GO:0006464: protein modification process (biological_process)
GO:0006464: protein modification process (biological_process)
GO:0051188: cofactor biosynthetic process (biological_process)
GO:0051188: cofactor biosynthetic process (biological_process)
GO:0051188: cofactor biosynthetic process (biological_process)
GO:0051188: cofactor biosynthetic process (biological_process)
GO:0051188: cofactor biosynthetic process (biological_process)
GO:0051188: cofactor biosynthetic process (biological_process)
GO:0006464: protein modification process (biological_process)
GO:0006464: protein modification process (biological_process)
GO:0006464: protein modification process (biological_process)
GO:0051188: cofactor biosynthetic process (biological_process)
GO:0051188: cofactor biosynthetic process (biological_process)
GO:0051188: cofactor biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
iron hydrogenase, large subunitFe_largYESTIGR02512 (HMM): [FeFe] hydrogenase, group A
iron hydrogenase, large subunitFe_largYESTIGR02512 (HMM): [FeFe] hydrogenase, group A
iron hydrogenase, large subunitFe_largYESTIGR02512 (HMM): [FeFe] hydrogenase, group A
iron hydrogenase, small subunitFe_smalYESPF02256 (HMM): iron hydrogenase, small subunit
iron hydrogenase, small subunitFe_smalYESPF02256 (HMM): iron hydrogenase, small subunit
iron hydrogenase, small subunitFe_smalYESPF02256 (HMM): iron hydrogenase, small subunit
hydrogenase accessory rSAM protein HydEhydEYESTIGR03956 (HMM): [FeFe] hydrogenase H-cluster radical SAM maturase HydEGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase accessory rSAM protein HydEhydEYESTIGR03956 (HMM): [FeFe] hydrogenase H-cluster radical SAM maturase HydEGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase accessory rSAM protein HydEhydEYESTIGR03956 (HMM): [FeFe] hydrogenase H-cluster radical SAM maturase HydEGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase accessory GTP-binding protein HydFhydFYESTIGR03918 (HMM): [FeFe] hydrogenase H-cluster maturation GTPase HydFGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase accessory GTP-binding protein HydFhydFYESTIGR03918 (HMM): [FeFe] hydrogenase H-cluster maturation GTPase HydFGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase accessory GTP-binding protein HydFhydFYESTIGR03918 (HMM): [FeFe] hydrogenase H-cluster maturation GTPase HydFGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase accessory rSAM protein HydGhydGYESTIGR03955 (HMM): [FeFe] hydrogenase H-cluster radical SAM maturase HydGGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase accessory rSAM protein HydGhydGYESTIGR03955 (HMM): [FeFe] hydrogenase H-cluster radical SAM maturase HydGGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase accessory rSAM protein HydGhydGYESTIGR03955 (HMM): [FeFe] hydrogenase H-cluster radical SAM maturase HydGGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase putative regulatorhyd_TFNOTIGR03959 (HMM): putative iron-only hydrogenase system regulator
hydrogenase putative regulatorhyd_TFNOTIGR03959 (HMM): putative iron-only hydrogenase system regulator
hydrogenase putative regulatorhyd_TFNOTIGR03959 (HMM): putative iron-only hydrogenase system regulator

Parent Properties
AccessionName
GenProp0070energy metabolism
GenProp0070energy metabolism
GenProp0070energy metabolism


Sibling Properties
AccessionName
GenProp0011methanogenesis
GenProp0023glyoxylate shunt
GenProp0027photosynthesis
GenProp0033TCA cycle
GenProp0120pentose phosphate cycle
GenProp0131electron transport
GenProp0243ATP synthases
GenProp0298fermentation
GenProp0459D-xylose utilization (conversion to D-xylulose-5-phosphate)
GenProp0468Entner-Doudoroff pathway
GenProp0473arsenite oxidase
GenProp0611aerobic respiration
GenProp0636respiratory nitrate reductase
GenProp0637anaerobic dimethyl sulfoxide reductase
GenProp0638trimethylamine N-oxide reductase system
GenProp0682formate-dependent nitrite reductase, seven-gene type
GenProp0683cytochrome c nitrite reductase NrfHA
GenProp0691glycolysis
GenProp0695cytochrome b558/566
GenProp0723hydrogenase, nickel and F420-dependent
GenProp0737anaerobic glycerol-3-phosphate dehydrogenase complex
GenProp0755pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating
GenProp0756fumarate reductase complex
GenProp0764DMSO reductase family type II enzyme
GenProp08412-oxoacid:ferredoxin oxidoreductase
GenProp0856bacterio-opsin system
GenProp0915hydrogenase, mono-iron type
GenProp1089B12-dependent trimeric diol/glycerol dehydratase
GenProp1101quinoprotein cytochrome relay system