Genome Property Definition Page

AccessionGenProp0924
NameUDP-GlcNAc3N biosynthesis, GnnAB system
TypePATHWAY
DescriptionIn certain species including Acidithiobacillus ferrooxidans [1], Campylobacter jejuni [2] and Leptospira interrogans [3], the precursor of Lipid A of exopolysaccharide is a modified UDP-GlcNAc. This 2 gene system places an amino group at the 3-position in replacement of the usual hydroxy group.
Literature References
[ 1 ]Sweet CR, Ribeiro AA, Raetz CR  Oxidation and transamination of the 3-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans. Role in the formation of lipid a molecules with four amide-linked acyl chains.  J Biol Chem. 2004 Jun 11;279(24):25400-10. Epub 2004 Mar 24.  PMID 15044494
[ 2 ]van Mourik A, Steeghs L, van Laar J, Meiring HD, Hamstra HJ, van Putten JP, Wosten MM  Altered linkage of hydroxyacyl chains in lipid a of campylobacter jejuni reduces TLR4 activation and antimicrobial resistance.  J Biol Chem. 2010 Mar 29.  PMID 20351099
[ 3 ]Que-Gewirth NL, Ribeiro AA, Kalb SR, Cotter RJ, Bulach DM, Adler B, Girons IS, Werts C, Raetz CR  A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2.  J Biol Chem. 2004 Jun 11;279(24):25420-9. Epub 2004 Mar 24.  PMID 15044492

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
UDP-GlcNAc 3-dehydrogenaseGnnAYES
3-dehydro-UDP-GlcNAc 3-aminotransferaseGnnBYES
source of UDP-GlcNAcUGlcNAcYESGenProp0750 (HMM)