Genome Property Definition Page

AccessionGenProp0927
Namebacillithiol biosynthesis
TypePATHWAY
DescriptionThis property describes the biosynthesis of bacillithiol, a thiol analog of glutathione and mycothiol. Bacillithiol is a 398-Da alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid
JCVI RoleGlutathione and analogs
Parent PropertyGenProp0184: cofactor biosynthesis
GenProp0184: cofactor biosynthesis
GenProp0184: cofactor biosynthesis
Literature References
[ 1 ]Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD  Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.  Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6482-6. Epub 2010 Mar 22.  PMID 20308541
[ 2 ]Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A  Characterization of the N-Acetyl-alpha-d-glucosaminyl l-Malate Synthase and Deacetylase Functions for Bacillithiol Biosynthesis in Bacillus anthracis .  Biochemistry. 2010 Sep 28;49(38):8398-414.  PMID 20799687
[ 1 ]Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD  Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.  Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6482-6. Epub 2010 Mar 22.  PMID 20308541
[ 2 ]Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A  Characterization of the N-Acetyl-alpha-d-glucosaminyl l-Malate Synthase and Deacetylase Functions for Bacillithiol Biosynthesis in Bacillus anthracis .  Biochemistry. 2010 Sep 28;49(38):8398-414.  PMID 20799687
[ 1 ]Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD  Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.  Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6482-6. Epub 2010 Mar 22.  PMID 20308541
[ 2 ]Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A  Characterization of the N-Acetyl-alpha-d-glucosaminyl l-Malate Synthase and Deacetylase Functions for Bacillithiol Biosynthesis in Bacillus anthracis .  Biochemistry. 2010 Sep 28;49(38):8398-414.  PMID 20799687
Gene Ontology TermGO:0071793: bacillithiol biosynthetic process (biological_process)
GO:0071793: bacillithiol biosynthetic process (biological_process)
GO:0071793: bacillithiol biosynthetic process (biological_process)
GO:0071793: bacillithiol biosynthetic process (biological_process)
GO:0071793: bacillithiol biosynthetic process (biological_process)
GO:0071793: bacillithiol biosynthetic process (biological_process)
GO:0071793: bacillithiol biosynthetic process (biological_process)
GO:0071793: bacillithiol biosynthetic process (biological_process)
GO:0071793: bacillithiol biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
glycosyltransferase BshABshAYESTIGR03999 (HMM): N-acetyl-alpha-D-glucosaminyl L-malate synthase BshAGO:0071793: bacillithiol biosynthetic process
glycosyltransferase BshABshAYESTIGR03999 (HMM): N-acetyl-alpha-D-glucosaminyl L-malate synthase BshAGO:0071793: bacillithiol biosynthetic process
glycosyltransferase BshABshAYESTIGR03999 (HMM): N-acetyl-alpha-D-glucosaminyl L-malate synthase BshAGO:0071793: bacillithiol biosynthetic process
N-acetylhydrolase BshBBshBYESTIGR04000 (HMM): bacillithiol biosynthesis deacetylase BshB2
TIGR04001 (HMM): bacillithiol biosynthesis deacetylase BshB1
GO:0071793: bacillithiol biosynthetic process
GO:0071793: bacillithiol biosynthetic process
N-acetylhydrolase BshBBshBYESTIGR04000 (HMM): bacillithiol biosynthesis deacetylase BshB2
TIGR04001 (HMM): bacillithiol biosynthesis deacetylase BshB1
GO:0071793: bacillithiol biosynthetic process
GO:0071793: bacillithiol biosynthetic process
N-acetylhydrolase BshBBshBYESTIGR04000 (HMM): bacillithiol biosynthesis deacetylase BshB2
TIGR04001 (HMM): bacillithiol biosynthesis deacetylase BshB1
GO:0071793: bacillithiol biosynthetic process
GO:0071793: bacillithiol biosynthetic process
cysteine-adding enzyme BshCBshCYESTIGR03998 (HMM): bacillithiol biosynthesis cysteine-adding enzyme BshCGO:0071793: bacillithiol biosynthetic process
cysteine-adding enzyme BshCBshCYESTIGR03998 (HMM): bacillithiol biosynthesis cysteine-adding enzyme BshCGO:0071793: bacillithiol biosynthetic process
cysteine-adding enzyme BshCBshCYESTIGR03998 (HMM): bacillithiol biosynthesis cysteine-adding enzyme BshCGO:0071793: bacillithiol biosynthetic process

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis
GenProp0184cofactor biosynthesis
GenProp0184cofactor biosynthesis


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp1064ovothiol biosynthesis
GenProp1096coenzyme B biosynthesis