Genome Property Definition Page

AccessionGenProp0928
NameOMP chaperone system: SurA-Skp-DegP
TypeSYSTEM
DescriptionOuter membrane beta-barrel proteins are translocated into the periplasm by the Sec system and subsequently properly folded and inserted into the outer membrane by the beta-barrel assembly machine (Bam). In the periplasm chaperones prevent misfolding and aggregation and facilitate the transit across the periplasmic space. The SurA protein appears to be the primary chaperone, at least in E. coli [1], while Skp and DegP may act to rescue any OMPs which fall off of the SurA complex.
Parent PropertyGenProp0179: protein transport
GenProp0248: protein folding
GenProp0725: outer membrane protein assembly complex
Literature References
[ 1 ]Sklar JG, Wu T, Kahne D, Silhavy TJ  Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli.  Genes Dev. 2007 Oct 1;21(19):2473-84.  PMID 17908933
Gene Ontology TermGO:0006886: intracellular protein transport (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
chaperone DegPDegPYESTIGR02037 (HMM): peptidase DoGO:0006886: intracellular protein transport
chaperone SkpSkpYESPF03938 (HMM): outer membrane protein, OmpH-likeGO:0006886: intracellular protein transport
chaperone SurASurAYESPF09312 (HMM): SurA N-terminal domainGO:0006886: intracellular protein transport

Parent Properties
AccessionName
GenProp0179protein transport
GenProp0248protein folding
GenProp0725outer membrane protein assembly complex


Sibling Properties
AccessionName
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0847exosporium
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N
GenProp0244chaperone system: DnaK-DnaJ-GrpE
GenProp0245chaperone system: GroEL/GroES
GenProp0246chaperone system: thermosome/prefoldin
GenProp0725outer membrane protein assembly complex