Genome Property Definition Page

AccessionGenProp0943
Namepyruvate formate-lyase system
TypeSYSTEM
DescriptionThis property consists of the glycine radical enzyme, pyruvate-formate lyase (EC 2.3.1.54, also called formate C-acetyltransferase) and its activating enzyme, [Formate-C-acetyltransferase]-activating enzyme (EC 1.97.1.4). In most Proteobacteria, the gene pair is accompanied by the formate channel gene focA. FocA forms a pentameric channel that can pass formate but not water, and that belongs to the same transporter family as nitrate transporter NirC.
Parent PropertyGenProp0075: protein modification, prosthetic groups and cofactors
GenProp0075: protein modification, prosthetic groups and cofactors
GenProp0075: protein modification, prosthetic groups and cofactors
Literature References
[ 1 ]Wagner AF, Schultz S, Bomke J, Pils T, Lehmann WD, Knappe J  YfiD of Escherichia coli and Y06I of bacteriophage T4 as autonomous glycyl radical cofactors reconstituting the catalytic center of oxygen-fragmented pyruvate formate-lyase.  Biochem Biophys Res Commun. 2001 Jul 13;285(2):456-62.  PMID 11444864
[ 1 ]Wagner AF, Schultz S, Bomke J, Pils T, Lehmann WD, Knappe J  YfiD of Escherichia coli and Y06I of bacteriophage T4 as autonomous glycyl radical cofactors reconstituting the catalytic center of oxygen-fragmented pyruvate formate-lyase.  Biochem Biophys Res Commun. 2001 Jul 13;285(2):456-62.  PMID 11444864
[ 1 ]Wagner AF, Schultz S, Bomke J, Pils T, Lehmann WD, Knappe J  YfiD of Escherichia coli and Y06I of bacteriophage T4 as autonomous glycyl radical cofactors reconstituting the catalytic center of oxygen-fragmented pyruvate formate-lyase.  Biochem Biophys Res Commun. 2001 Jul 13;285(2):456-62.  PMID 11444864

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
pyruvate formate-lyasePFLYESTIGR01774 (HMM): glycyl radical enzyme, PFL2/glycerol dehydratase family
TIGR01255 (HMM): formate acetyltransferase
pyruvate formate-lyasePFLYESTIGR01774 (HMM): glycyl radical enzyme, PFL2/glycerol dehydratase family
TIGR01255 (HMM): formate acetyltransferase
pyruvate formate-lyasePFLYESTIGR01774 (HMM): glycyl radical enzyme, PFL2/glycerol dehydratase family
TIGR01255 (HMM): formate acetyltransferase
pyruvate formate-lyase activating enzymePFLAYESTIGR02493 (HMM): pyruvate formate-lyase 1-activating enzyme
pyruvate formate-lyase activating enzymePFLAYESTIGR02493 (HMM): pyruvate formate-lyase 1-activating enzyme
pyruvate formate-lyase activating enzymePFLAYESTIGR02493 (HMM): pyruvate formate-lyase 1-activating enzyme
formate transporterPF_FocANOPF01226 (HMM-CLUST): formate/nitrite transporter
formate transporterPF_FocANOPF01226 (HMM-CLUST): formate/nitrite transporter
formate transporterPF_FocANOPF01226 (HMM-CLUST): formate/nitrite transporter
autonomous glycyl radical cofactorspareNOTIGR04365 (HMM): autonomous glycyl radical cofactor GrcA
autonomous glycyl radical cofactorspareNOTIGR04365 (HMM): autonomous glycyl radical cofactor GrcA
autonomous glycyl radical cofactorspareNOTIGR04365 (HMM): autonomous glycyl radical cofactor GrcA

Parent Properties
AccessionName
GenProp0075protein modification, prosthetic groups and cofactors
GenProp0075protein modification, prosthetic groups and cofactors
GenProp0075protein modification, prosthetic groups and cofactors


Sibling Properties
AccessionName
GenProp0002coenzyme F420 utilization
GenProp0016selenocysteine system
GenProp0061lipoprotein system lgt/lsp/lnt
GenProp0127Tat (Sec-independent) protein export
GenProp0284cobalamin-utilizing enzymes
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0726selenium-dependent molybdenum hydroxylase system
GenProp0745lipoyl-protein attachment
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0918anaerobic sulfatase/maturase system
GenProp0923mycothiol system
GenProp0933bacillithiol utilization
GenProp0938glycine radical enzyme system, YjjI/YjjW pair