Genome Property Definition Page

NameGDP-L-colitose biosynthesis
DescriptionGDP-L-colitose, a 3,6-dideoxy hexose sugar is formed from GDP-4-ket-6-deoxymannose in a two-step reaction carried out by the ColC and ColD gene products. Colitose is a component of the O111 and O55 E. coli O-antigens.
JCVI RoleBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Literature References
[ 1 ]Alam J, Beyer N, Liu HW  Biosynthesis of colitose: expression, purification, and mechanistic characterization of GDP-4-keto-6-deoxy-D-mannose-3-dehydrase (ColD) and GDP-L-colitose synthase (ColC).  Biochemistry. 2004 Dec 28;43(51):16450-60.  PMID 15610039

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
GDP-L-colitose synthaseColCYES2745 (RULE_BASE)
GDP-4-keto-6-deoxy-D-mannose-3-dehydrataseColDYES2744 (RULE_BASE)
source of GDP-4-keto-6-deoxymannoseGDP-KDMYESGenProp0930 (GENPROP): GDP-4-keto-6-deoxymannose biosynthesis from b-D-fructose-6-phosphate