Genome Property Definition Page
| Accession | GenProp0947 | |
| Name | O55(Ec) antigen biosynthesis | |
| Type | METAPATH | |
| Description | The O55 O-antigen is observed in E. coli strain CB9615 and AE. The structure of the O55 antigen is a branched pentasaccharide containing one colitose sugar [1]. The O55 biosynthetic cluster encodes four sugar transferases WbgMNOP, the wzx, wzy and wzz components as well as the enzymes for the biosynthesis of GDP-L-colitose from D-fructose-6P via GDP-mannose. | |
| JCVI Role | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides | |
| Parent Property | GenProp0913: E. coli O-antigen monomer biosynthesis clusters | |
| Literature References |
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Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| source of GDP-colitose | GDP-Col | YES | GenProp0946 (GENPROP): GDP-L-colitose biosynthesis | |
| a-D-Gal-(1->3)-b-D-GalNAc transferase | WbgM | YES | 2753 (RULE_BASE) | |
| a-Col-(1->2)-b-D-Gal transferase | WbgN | YES | 2752 (RULE_BASE) | |
| b-D-Gal-(1->3)-b-D-GlcNAc transferase | WbgO | YES | 2747 (RULE_BASE) | |
| b-D-GlcNAc-(1->3)-a-D-Gal transferase | WbgP | YES | 2746 (RULE_BASE) | |
| O55-specific transporter (flippase) | wzx55 | YES | 2750 (RULE_BASE) | |
| O55-specific polymerase | wzy55 | YES | 2751 (RULE_BASE) | |
| chain length determinant protein | wzz | NO | PF02706 (HMM-CLUST): chain length determinant protein |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0913 | E. coli O-antigen monomer biosynthesis clusters |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0932 | O104(Ec) antigen biosynthesis |
| GenProp0949 | O111(Ec) antigen biosynthesis |
| GenProp0953 | O103(Ec) antigen biosynthesis |
| GenProp0963 | O2(Ec) antigen biosynthesis |
| GenProp1014 | O5(Ec) antigen biosynthesis |
| GenProp1018 | O8(Ec) antigen biosynthesis |
| GenProp1042 | O128(Ec) antigen biosynthesis |